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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4839742 Functional Antagonist activity at mouse CaSR Mus musculus 1 ALA4837255 assay format Scientific Literature 2. ALA4839743 ADME Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity at 50 uM preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay relative to control Homo sapiens 8 ALA4837255 cell-based format Scientific Literature 3. ALA4839744 ADME Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay Homo sapiens 8 ALA4837255 cell-based format Scientific Literature 4. ALA4839745 ADME AUC (0 to t) in mouse at 300 mg/kg/day, po measured after 1 day Mus musculus 1 ALA4837255 organism-based format Scientific Literature 5. ALA4839746 ADME AUC (0 to t) in mouse at 1000 mg/kg/day, po measured after 1 day Mus musculus 1 ALA4837255 organism-based format Scientific Literature 6. ALA4839747 ADME AUC (0 to t) in mouse at 2000 mg/kg/day, po measured after 1 day Mus musculus 1 ALA4837255 organism-based format Scientific Literature 7. ALA4839748 ADME AUC (0 to t) in mouse at 300 mg/kg/day, po measured after 10 days Mus musculus 1 ALA4837255 organism-based format Scientific Literature 8. ALA4839749 ADME AUC (0 to t) in mouse at 1000 mg/kg/day, po measured after 10 days Mus musculus 1 ALA4837255 organism-based format Scientific Literature 9. ALA4839750 ADME AUC (0 to t) in mouse at 2000 mg/kg/day, po measured after 10 days Mus musculus 1 ALA4837255 organism-based format Scientific Literature 10. ALA4839751 ADME Cmax in mouse at 300 mg/kg/day, po measured after 1 day Mus musculus 1 ALA4837255 organism-based format Scientific Literature 11. ALA4839752 ADME Cmax in mouse at 1000 mg/kg/day, po measured after 1 day Mus musculus 1 ALA4837255 organism-based format Scientific Literature 12. ALA4839753 ADME Cmax in mouse at 2000 mg/kg/day, po measured after 1 day Mus musculus 1 ALA4837255 organism-based format Scientific Literature 13. ALA4839754 ADME Cmax in mouse at 300 mg/kg/day, po measured after 10 days Mus musculus 1 ALA4837255 organism-based format Scientific Literature 14. ALA4839755 ADME Cmax in mouse at 1000 mg/kg/day, po measured after 10 days Mus musculus 1 ALA4837255 organism-based format Scientific Literature 15. ALA4839756 ADME Cmax in mouse at 2000 mg/kg/day, po measured after 10 days Mus musculus 1 ALA4837255 organism-based format Scientific Literature 16. ALA4839757 Functional Antagonist activity at human CaSR in human HEK293 cells measured after 5 mins by FLIPR assay Homo sapiens 8 ALA4837255 cell-based format Scientific Literature 17. ALA4839758 ADME AUC (0 to t) in rat at 300 mg/kg/day measured after 1 day Rattus norvegicus 1 ALA4837255 organism-based format Scientific Literature 18. ALA4839760 ADME AUC (0 to t) in rat at 300 mg/kg/day measured after 10 days Rattus norvegicus 1 ALA4837255 organism-based format Scientific Literature 19. ALA4839762 ADME Cmax in rat at 300 mg/kg/day measured after 1 day Rattus norvegicus 1 ALA4837255 organism-based format Scientific Literature 20. ALA4839764 ADME Cmax in rat at 300 mg/kg/day measured after 10 days Rattus norvegicus 1 ALA4837255 organism-based format Scientific Literature