| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4839742 | F | Antagonist activity at mouse CaSR | Mus musculus | 1 | assay format | Scientific Literature | ||
| 2. | ALA4839743 | A | Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity at 50 uM preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA4839744 | A | Activation of full length human PXR expressed in human HepG2 cells co-expressing luciferase of CYP3A4 promoter transcription assessed as increase of luciferase activity preincubated for 24 hrs followed by addition of luciferase substrate and measured by hPXR Gene reporter assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 4. | ALA4839745 | A | AUC (0 to t) in mouse at 300 mg/kg/day, po measured after 1 day | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 5. | ALA4839746 | A | AUC (0 to t) in mouse at 1000 mg/kg/day, po measured after 1 day | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 6. | ALA4839747 | A | AUC (0 to t) in mouse at 2000 mg/kg/day, po measured after 1 day | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4839748 | A | AUC (0 to t) in mouse at 300 mg/kg/day, po measured after 10 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4839749 | A | AUC (0 to t) in mouse at 1000 mg/kg/day, po measured after 10 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4839750 | A | AUC (0 to t) in mouse at 2000 mg/kg/day, po measured after 10 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4839751 | A | Cmax in mouse at 300 mg/kg/day, po measured after 1 day | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4839752 | A | Cmax in mouse at 1000 mg/kg/day, po measured after 1 day | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4839753 | A | Cmax in mouse at 2000 mg/kg/day, po measured after 1 day | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4839754 | A | Cmax in mouse at 300 mg/kg/day, po measured after 10 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4839755 | A | Cmax in mouse at 1000 mg/kg/day, po measured after 10 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4839756 | A | Cmax in mouse at 2000 mg/kg/day, po measured after 10 days | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4839757 | F | Antagonist activity at human CaSR in human HEK293 cells measured after 5 mins by FLIPR assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 17. | ALA4839758 | A | AUC (0 to t) in rat at 300 mg/kg/day measured after 1 day | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4839760 | A | AUC (0 to t) in rat at 300 mg/kg/day measured after 10 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4839762 | A | Cmax in rat at 300 mg/kg/day measured after 1 day | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4839764 | A | Cmax in rat at 300 mg/kg/day measured after 10 days | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!