# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4824258 | Binding | Inhibition of Trypanosoma brucei TryR oxidoreductase activity using TS2 as substrate by spectrophotometric assay | Trypanosoma brucei | 7 | ALA4823264 | single protein format | Scientific Literature | |
2. | ALA4824259 | Binding | Inhibition of Trypanosoma congolense TryR oxidoreductase activity using TS2 as substrate by spectrophotometric assay | Trypanosoma congolense | 7 | ALA4823264 | assay format | Scientific Literature | |
3. | ALA4824261 | Functional | Antileishmanial activity against promastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 23 | ALA4823264 | organism-based format | Scientific Literature | |
4. | ALA4824262 | Functional | Antileishmanial activity against axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 23 | ALA4823264 | organism-based format | Scientific Literature | |
5. | ALA4824263 | ADME | Cytotoxicity against human HepG2 cells incubated for 24 hrs by crystal violet staining based assay | Homo sapiens | 23 | ALA4823264 | cell-based format | Scientific Literature | |
6. | ALA4824264 | Toxicity | Selectivity index, ratio of EC50 for human HepG2 cells to EC50 for promastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells | 23 | ALA4823264 | cell-based format | Scientific Literature | ||
7. | ALA4824265 | Toxicity | Selectivity index, ratio of EC50 for human HepG2 cells to EC50 for axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells | 23 | ALA4823264 | cell-based format | Scientific Literature | ||
8. | ALA4824266 | Functional | Leishmanicidal activity against axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human THP-1 macrophage cells assessed as reduction in intracellular amastigotes incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 13 | ALA4823264 | organism-based format | Scientific Literature | |
9. | ALA4824267 | ADME | Cytotoxicity against human THP-1 cells by LDH assay | Homo sapiens | 13 | ALA4823264 | cell-based format | Scientific Literature | |
10. | ALA4824269 | Toxicity | Selectivity index, ratio of EC50 for human THP-1 macrophage cells to EC50 for Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human THP-1 macrophage cells | 2 | ALA4823264 | assay format | Scientific Literature |