# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4824242 | B | Inhibition of recombinant His-tagged Leishmania infantum TryR oxidoreductase activity expressed in Escherichia coli BL2(DE3) using TS2 as substrate by spectrophotometric assay | Leishmania infantum | 29 | ALA4823264 | assay format | Scientific Literature | |
2. | ALA4824244 | B | Inhibition of recombinant His-FLAG-tagged Leishmania infantum TryR dimerization expressed in Escherichia coli BL2(DE3) assessed as reduction in TryR dimer using TS2 as substrate after 16 hrs by ELISA | Leishmania infantum | 27 | ALA4823264 | assay format | Scientific Literature | |
3. | ALA4824246 | B | Inhibition of recombinant human GR oxidoreductase activity by DTNB-reagent based spectrophotometric method | Homo sapiens | 6 | ALA4823264 | single protein format | Scientific Literature | |
4. | ALA4824258 | B | Inhibition of Trypanosoma brucei TryR oxidoreductase activity using TS2 as substrate by spectrophotometric assay | Trypanosoma brucei | 7 | ALA4823264 | single protein format | Scientific Literature | |
5. | ALA4824259 | B | Inhibition of Trypanosoma congolense TryR oxidoreductase activity using TS2 as substrate by spectrophotometric assay | Trypanosoma congolense | 7 | ALA4823264 | assay format | Scientific Literature | |
6. | ALA4824261 | F | Antileishmanial activity against promastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 23 | ALA4823264 | organism-based format | Scientific Literature | |
7. | ALA4824262 | F | Antileishmanial activity against axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells incubated for 24 hrs by propidium iodide staining based flow cytometry | Leishmania infantum | 23 | ALA4823264 | organism-based format | Scientific Literature | |
8. | ALA4824263 | A | Cytotoxicity against human HepG2 cells incubated for 24 hrs by crystal violet staining based assay | Homo sapiens | 23 | ALA4823264 | cell-based format | Scientific Literature | |
9. | ALA4824264 | T | Selectivity index, ratio of EC50 for human HepG2 cells to EC50 for promastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells | 23 | ALA4823264 | cell-based format | Scientific Literature | ||
10. | ALA4824265 | T | Selectivity index, ratio of EC50 for human HepG2 cells to EC50 for axenic amastigote stage of Leishmania infantum MCAN/ES/89/IPZ229/1/89 infected in human HepG2 cells | 23 | ALA4823264 | cell-based format | Scientific Literature |