# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4808633 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 24 | ALA4808171 | cell-based format | Scientific Literature | |
2. | ALA4808634 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity at 10 uM incubated for 24 hrs hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay relative to TAK875 | Homo sapiens | 18 | ALA4808171 | cell-based format | Scientific Literature | |
3. | ALA4808635 | B | Agonist activity at human PPARgamma expressed in CHO cells assessed as increase in receptor transcriptional activity incubated for 24 hrs by dual luciferase reporter gene assay | Homo sapiens | 18 | ALA4808171 | cell-based format | Scientific Literature | |
4. | ALA4808636 | B | Agonist activity at human PPARgamma expressed in CHO cells assessed as increase in receptor transcriptional activity at 1 uM incubated for 24 hrs by dual luciferase reporter gene assay relative to rosiglitazone | Homo sapiens | 18 | ALA4808171 | cell-based format | Scientific Literature | |
5. | ALA4808637 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE (Gq) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 3 | ALA4808171 | cell-based format | Scientific Literature | |
6. | ALA4808638 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 3 | ALA4808171 | cell-based format | Scientific Literature | |
7. | ALA4808640 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells assessed as increase in cAMP level incubated for 30 mins by cAMP-Glo assay | Homo sapiens | 2 | ALA4808171 | cell-based format | Scientific Literature | |
8. | ALA4808641 | F | Agonist activity at GPR40 in mouse MIN6 cells assessed as fold increase in 17 mM glucose-mediated insulin secretion at 1 to 10 uM incubated for 2 hrs by ELISA relative to control | Mus musculus | 2 | ALA4808171 | cell-based format | Scientific Literature | |
9. | ALA4808642 | F | Agonist activity at GPR40 in mouse MIN6 cells assessed as fold increase in 17 mM glucose-mediated insulin secretion at 1 to 10 uM incubated for 2 hrs in presence of GW1100 by ELISA relative to control | Mus musculus | 3 | ALA4808171 | cell-based format | Scientific Literature | |
10. | ALA4808643 | F | Agonist activity at GPR40 in mouse MIN6 cells assessed as fold increase in 3 mM glucose-mediated insulin secretion at 10 uM incubated for 2 hrs by ELISA relative to control | Mus musculus | 3 | ALA4808171 | cell-based format | Scientific Literature | |
11. | ALA4808644 | F | Induction of GLP-1 secretion in human STC1 cells at 30 uM after 1 hrs by ELISA | Homo sapiens | 2 | ALA4808171 | cell-based format | Scientific Literature | |
12. | ALA4808646 | A | Cytotoxicity in mouse MIN6 cells assessed as caspase 3/7 activity at 100 uM incubated for 72 hrs by fluorescence assay | Mus musculus | 2 | ALA4808171 | cell-based format | Scientific Literature | |
13. | ALA4808647 | F | Effect on BSA-PA conjugate-induced lipo-toxicity in mouse MIN6 cells assessed as caspase 3/7 activity at 50 uM incubated for 72 hrs by fluorescence assay | Mus musculus | 2 | ALA4808171 | cell-based format | Scientific Literature | |
14. | ALA4808648 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance | Mus musculus | 2 | ALA4808171 | microsome format | Scientific Literature | |
15. | ALA4808649 | A | Metabolic stability in human liver microsomes assessed as intrinsic clearance | Homo sapiens | 2 | ALA4808171 | microsome format | Scientific Literature | |
16. | ALA4808650 | A | Half life in CD-1 mouse at 10 mg/kg, po measured up to 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4808171 | organism-based format | Scientific Literature | |
17. | ALA4808651 | A | Half life in CD-1 mouse at 30 mg/kg, po measured up to 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4808171 | organism-based format | Scientific Literature | |
18. | ALA4808652 | A | Half life in CD-1 mouse at 90 mg/kg, po measured up to 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4808171 | organism-based format | Scientific Literature | |
19. | ALA4808653 | A | Tmax in CD-1 mouse at 10 mg/kg, po measured up to 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4808171 | organism-based format | Scientific Literature | |
20. | ALA4808654 | A | Tmax in CD-1 mouse at 30 mg/kg, po measured up to 8 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4808171 | organism-based format | Scientific Literature |