# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4834836 | Binding | Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells at 1 uM incubated for 60 mins by scintillation counting analysis relative to control | Homo sapiens | 23 | ALA4834400 | cell-based format | Scientific Literature | |
2. | ALA4834837 | Binding | Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells at 1 uM incubated for 120 mins by scintillation counting analysis relative to control | Homo sapiens | 23 | ALA4834400 | cell-based format | Scientific Literature | |
3. | ALA4834838 | Binding | Displacement of 2-[1251]-iodomelatonin from human MT1 receptor expressed in CHO cells incubated for 60 mins by scintillation counting analysis | Homo sapiens | 23 | ALA4834400 | cell-based format | Scientific Literature | |
4. | ALA4834839 | Binding | Displacement of 2-[1251]-iodomelatonin from human MT2 receptor expressed in CHO cells incubated for 120 mins by scintillation counting analysis | Homo sapiens | 23 | ALA4834400 | cell-based format | Scientific Literature | |
5. | ALA4834840 | Functional | Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in forskolin induced cAMP production incubated at 37 degreeC by HitHunter-cAMP assay | Homo sapiens | 9 | ALA4834400 | cell-based format | Scientific Literature | |
6. | ALA4834841 | Functional | Agonist activity at human MT2 receptor expressed in CHO cells assessed as increase in cAMP production incubated at 37 degreeC by fluorometric method | Homo sapiens | 23 | ALA4834400 | cell-based format | Scientific Literature | |
7. | ALA4834842 | Physicochemical | n-octanol/aqueous phosphate buffer distribution coefficient, logD of compound at pH 7.4 incubated for 1 hr by shake flask assay based HPLC-MS/MS analysis | 9 | ALA4834400 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4834843 | Physicochemical | Dissociation constant, pKa of the compound by UV-vis spectrophotometric analysis | 9 | ALA4834400 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4834844 | ADME | Apparent permeability of compound across apical to basolateral side in human Caco-2 cells at 10 uM incubated for 60 mins by HPLC-MS/MS analysis | Homo sapiens | 9 | ALA4834400 | cell-based format | Scientific Literature | |
10. | ALA4834845 | ADME | Apparent permeability of compound across basolateral to apical side in human Caco-2 cells at 10 uM incubated for 40 mins by HPLC-MS/MS analysis | Homo sapiens | 9 | ALA4834400 | cell-based format | Scientific Literature | |
11. | ALA4834846 | Physicochemical | Kinetic solubility of compound in PBS at pH 7.4 incubated for 24 hrs by HPLC-UV/Visible analysis | 9 | ALA4834400 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4834847 | ADME | Half life in human cryopreserved hepatocytes at 1 uM incubated upto 2 hrs by HPLC-MS/MS analysis | Homo sapiens | 9 | ALA4834400 | cell-based format | Scientific Literature | |
13. | ALA4834848 | ADME | Half life in Sprague-Dawley rat hepatocytes at 1 uM incubated upto 2 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 9 | ALA4834400 | cell-based format | Scientific Literature | |
14. | ALA4834849 | ADME | Half life in CD1 mouse hepatocytes at 1 uM incubated upto 2 hrs by HPLC-MS/MS analysis | Mus musculus | 9 | ALA4834400 | cell-based format | Scientific Literature | |
15. | ALA4834850 | ADME | Intrinsic clearance in human cryopreserved hepatocytes assessed per million cells at 1 uM incubated upto 2 hrs by HPLC-MS/MS analysis | Homo sapiens | 9 | ALA4834400 | cell-based format | Scientific Literature | |
16. | ALA4834851 | ADME | Intrinsic clearance in Sprague-Dawley rat hepatocytes assessed per million cells at 1 uM incubated upto 2 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 9 | ALA4834400 | cell-based format | Scientific Literature | |
17. | ALA4834852 | ADME | Intrinsic clearance in CD1 mouse hepatocytes assessed per million cells at 1 uM incubated upto 2 hrs by HPLC-MS/MS analysis | Mus musculus | 9 | ALA4834400 | cell-based format | Scientific Literature | |
18. | ALA4834853 | Functional | Agonist activity at human MT1 receptor expressed in CHO cells assessed as increase in cAMP levels incubated at 28 degreeC by cellular dielectric spectroscopic analysis | Homo sapiens | 23 | ALA4834400 | cell-based format | Scientific Literature | |
19. | ALA4834854 | ADME | Clearance in Wistar Han rat at 1 mg/kg, iv | Rattus norvegicus | 8 | ALA4834400 | organism-based format | Scientific Literature | |
20. | ALA4834856 | ADME | Clearance in CD1 mouse at 1 mg/kg, iv | Mus musculus | 9 | ALA4834400 | organism-based format | Scientific Literature |