| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4835172 | B | Inhibition of human recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assay | Homo sapiens | 60 | single protein format | Scientific Literature | ||
| 2. | ALA4835173 | B | Inhibition of rat recombinant ADAMTS-5 assessed as cleavage of fluorescent substrate using FAM-TBIS-1 by biochemical assay | Rattus norvegicus | 4 | assay format | Scientific Literature | ||
| 3. | ALA4835175 | B | Inhibition of human recombinant ADAMTS-4 (AA1 to 520) assessed as cleavage of fluorescent substrate using as TBIS-1 substrate incubated for 180 mins by biochemical assay | Homo sapiens | 14 | single protein format | Scientific Literature | ||
| 4. | ALA4835191 | A | Intrinsic clearance in human liver microsomes | Homo sapiens | 4 | microsome format | Scientific Literature | ||
| 5. | ALA4835192 | A | Intrinsic clearance in rat liver microsomes | Rattus norvegicus | 4 | microsome format | Scientific Literature | ||
| 6. | ALA4835193 | A | Inhibition of CYP1A2 (unknown origin) at 10 uM | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 7. | ALA4835194 | A | Inhibition of CYP1C19 (unknown origin) at 10 uM | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 8. | ALA4835195 | A | Inhibition of CYP2C9 (unknown origin) at 10 uM | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 9. | ALA4835196 | A | Inhibition of CYP2D6 (unknown origin) at 10 uM | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 10. | ALA4835197 | A | Inhibition of CYP3A4 (unknown origin) using BFC as substrate at 10 uM | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 11. | ALA4835198 | A | Inhibition of CYP3A4 (unknown origin) using DBF as substrate at 10 uM | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 12. | ALA4835199 | A | Plasma protein binding in rat at 5 uM measured after 4 hrs by LC-MS/MS analysis | Rattus norvegicus | 4 | cell-free format | Scientific Literature | ||
| 13. | ALA4835203 | B | Inhibition of human ERG expressed in HEK293 cells measured at holding potential -80 mV at 10 uM by whole cell patch clam method | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 14. | ALA4835204 | A | AUC in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 15. | ALA4835205 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, po | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 16. | ALA4835209 | A | Plasma protein binding in human at 5 uM measured after 4 hrs by LC-MS/MS analysis | Homo sapiens | 6 | cell-free format | Scientific Literature | ||
| 17. | ALA4835210 | B | Inhibition of ADAMTS-5 in C57BL/6 mouse femoral head cartilage assessed as reduction in IL-1alpha stimulated glycosaminoglycan release at 1 uM measured after 3 days | Mus musculus | 2 | tissue-based format | Scientific Literature | ||
| 18. | ALA4835211 | B | Inhibition of ADAMTS-5 in C57BL/6 mouse femoral head cartilage assessed as reduction in IL-1alpha stimulated glycosaminoglycan release at 3 uM measured after 3 days | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 19. | ALA4835226 | A | Apparent permeability across apical to basolateral side in human Caco2 cells by LC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA4835254 | A | Intrinsic clearance in rat hepatocytes | Rattus norvegicus | 8 | cell-based format | Scientific Literature |
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