# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835698 | F | Antiproliferative activity against human RS4-11 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay | Homo sapiens | 33 | cell-based format | Scientific Literature | ||
2. | ALA4835757 | B | Molecular glue activity at CRBN/MDM2 in human RS4-11 cells assessed as induction of MDM2 degradation by measuring MDM2 level at 10 nM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
3. | ALA4835758 | B | Molecular glue activity at CRBN/MDM2 in human RS4-11 cells assessed as induction of MDM2 degradation by measuring MDM2 level at 100 nM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4835761 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 10 nM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
5. | ALA4835762 | B | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 100 nM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
6. | ALA4835765 | B | Molecular glue activity at CRBN/GSPT1 in human RS4-11 cells assessed as induction of GSPT1 degradation by measuring GSPT1 level at 10 nM measured after 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
7. | ALA4835766 | B | Molecular glue activity at CRBN/GSPT1 in human RS4-11 cells assessed as induction of GSPT1 degradation by measuring GSPT1 level at 100 nM measured after 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 2 | cell-based format | Scientific Literature |