| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4814083 | B | Inhibition of HOXA9 (unknown origin) expressed in reticulocyte lysate system binding to DNA Hoxa9-binding site (5'-biotin-cctctcctctcctGCGATGATTTACGACCGC) (unknown origin) assessed as Hoxa9/DNA remaining complexes at 5 to 10 uM incubated for 20 mins with DNA followed by compound wash out and subsequent HOXA9 addition and measured after 1 hr by ELISA | 39 | subcellular format | Scientific Literature | |||
| 2. | ALA4827162 | A | Cytotoxicity against rat L6 cells by Alamar blue assay | Rattus norvegicus | 16 | cell-based format | Scientific Literature | ||
| 3. | ALA4827163 | B | Binding affinity to poly (dA-dT) (unknown origin) assessed as thermal stability by measuring change in melting temperature | Not specified | 10 | nucleic acid format | Scientific Literature | ||
| 4. | ALA4827164 | F | Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 measured after 72 hrs by alamar blue dye based fluorimetry analysis | Trypanosoma brucei rhodesiense | 16 | organism-based format | Scientific Literature | ||
| 5. | ALA4827165 | F | Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human erythrocytes assessed as reduction in [3H]hypoxanthine incorporation measured after 24 hrs by liquid scintillation counting method | Plasmodium falciparum | 16 | organism-based format | Scientific Literature | ||
| 6. | ALA4827166 | T | Selectivity index, ratio of IC50 for cytotoxicity against rat L6 cells to IC50 for antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 | 16 | cell-based format | Scientific Literature | |||
| 7. | ALA4827167 | T | Selectivity index, ratio of IC50 for cytotoxicity against rat L6 cells to IC50 for antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells | 16 | cell-based format | Scientific Literature | |||
| 8. | ALA4827168 | F | Antitrypanosomal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as reduction in parasitemia by measuring time taken to cure at 5 mg/kg, ip measured up to 60 days (Rvb = 11 days) | Trypanosoma brucei rhodesiense | 10 | organism-based format | Scientific Literature |
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