# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4819274 | B | Displacement of [3H]LSD from human 5-HT6 receptor expressed in HEK293 cells incubated for 1 hr by microbeta counting method | Homo sapiens | 21 | ALA4818985 | cell-based format | Scientific Literature | |
2. | ALA4819275 | B | Displacement of [3H]-Ketanserin from human 5-HT2A receptor expressed in CHO-K1 cells incubated for 1 hr by microbeta counting method | Homo sapiens | 19 | ALA4818985 | cell-based format | Scientific Literature | |
3. | ALA4819276 | B | Displacement of [3H]-5-CT from human 5-HT7R expressed in human HEK293 cells incubated for 1 hr by microbeta counting method | Homo sapiens | 20 | ALA4818985 | cell-based format | Scientific Literature | |
4. | ALA4819277 | B | Displacement of [3H]-raclopride from human D2L receptor expressed in HEK293 cells measured after 1 hr by microbeta counting method | Homo sapiens | 20 | ALA4818985 | cell-based format | Scientific Literature | |
5. | ALA4819278 | B | Binding affinity to human 5-HT6 receptor expressed in HEK293 cells | Homo sapiens | 5 | ALA4818985 | cell-based format | Scientific Literature | |
6. | ALA4819279 | F | Antagonist activity at human 5-HT6 expressed in human 1321N1 cells incubated for 30 mins by LANCE Ultra cAMP kit-based TR-FRET assay | Homo sapiens | 7 | ALA4818985 | cell-based format | Scientific Literature | |
7. | ALA4819280 | F | Agonist activity at human 5-HT6 expressed in human 1321N1 cells assessed as Emax incubated for 30 mins by LANCE Ultra cAMP kit-based TR-FRET assay relative to serotonin | Homo sapiens | 8 | ALA4818985 | cell-based format | Scientific Literature | |
8. | ALA4819281 | A | Permeability of the compound by PAMPA | 3 | ALA4818985 | assay format | Scientific Literature | ||
9. | ALA4819282 | A | Metabolic stability in rat liver microsomes assessed as compound remaining measured after 120 mins by LC-MS | Rattus norvegicus | 2 | ALA4818985 | microsome format | Scientific Literature | |
10. | ALA4819284 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 10 uM after 72 hrs by Cell-titer Glo assay | Homo sapiens | 1 | ALA4818985 | cell-based format | Scientific Literature | |
11. | ALA4819285 | F | Pro-cognitive activity in ip dosed Wistar rat assessed as inhibition of MK-801-induced memory impairment assessed as novel object recognition administered 60 mins and MK-801 administered 30 mins prior to T1 phase respectively by novel object recognition test | Rattus norvegicus | 1 | ALA4818985 | organism-based format | Scientific Literature | |
12. | ALA4819286 | F | Pro-cognitive activity in Wistar rat assessed as inhibition of MK-801-induced memory impairment assessed as recognition of novel location of at 3 mg/kg, ip administered 60 mins and MK-801 administered 30 mins prior to T1 phase respectively by novel object location test | Rattus norvegicus | 1 | ALA4818985 | organism-based format | Scientific Literature | |
13. | ALA5216596 | B | Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells by radioligand binding assay | Homo sapiens | 6 | ALA5214932 | cell-based format | Scientific Literature | |
14. | ALA5216597 | B | Displacement of [3H]-Raclopride from human 5-HT1AR expressed in HEK293 cells by radioligand binding assay | Homo sapiens | 6 | ALA5214932 | cell-based format | Scientific Literature | |
15. | ALA5216598 | B | Displacement of [3H]-Raclopride from human 5-HT2AR expressed in HEK293 cells by radioligand binding assay | Homo sapiens | 6 | ALA5214932 | cell-based format | Scientific Literature | |
16. | ALA5216599 | B | Displacement of [3H]-5Carboxyamidotryptamine from human 5-HT7R expressed in HEK293 cells by radioligand binding assay | Homo sapiens | 6 | ALA5214932 | cell-based format | Scientific Literature | |
17. | ALA5216600 | B | Displacement of [3H]-Raclopride from human dopamine D2 receptor expressed in HEK293 cells by radioligand binding assay | Homo sapiens | 6 | ALA5214932 | cell-based format | Scientific Literature | |
18. | ALA5216628 | B | Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells assessed as binding constant by radioligand binding assay | Homo sapiens | 6 | ALA5214932 | cell-based format | Scientific Literature |