| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4822135 | B | Binding affinity to Cereblon in human Flp293T cells transfected with BRD4(BD2)-GFP fusion protein and mCherry reporter assessed as inhibition of dBET6-induced BRD4(BD2) degradation after 5 hrs fluorescence based analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 2. | ALA4822141 | B | Protac activity at CRBN/SALL4 in human Kelly cells assessed as induction of SALL4 degradation by measuring downregulation of SALL4 protein expression at 1 uM measured after 5 hrs by proteomics analysis based LC-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4822142 | B | Protac activity at CRBN/ZNF692 in human Kelly cells assessed as induction of ZNF692 degradation by measuring downregulation of ZNF692 protein expression at 1 uM measured after 5 hrs by proteomics analysis based LC-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4822143 | B | Protac activity at CRBN/ZNF827 in human Kelly cells assessed as induction of ZNF827 degradation by measuring downregulation of ZNF827 protein expression at 1 uM measured after 5 hrs by proteomics analysis based LC-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4822144 | B | Protac activity at CRBN/eIF4E in human Kelly cells assessed as induction of eIF4E degradation by measuring downregulation of eIF4E protein expression at 1 uM measured after 5 hrs by proteomics analysis based LC-MS analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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