| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4838563 | B | Trapping activity at FGF in human KMS-11 cells assessed as inhibition of FGFR3 phosphorylation at 6 uM measured after 6 hrs by western blot analysis | Homo sapiens | 27 | cell-based format | Scientific Literature | ||
| 2. | ALA4838564 | F | Antiproliferative activity against human KMS-11 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 3. | ALA4838565 | B | Binding affinity to FGF2 (unknown origin) by sensor chip immobilization based surface plasmon resonance analysis | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 4. | ALA4838566 | B | Trapping activity at FGF in human OPM-2 cells assessed as inhibition of FGFR3 phosphorylation at 6 uM measured after 6 hrs by westernblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4838567 | B | Trapping activity at FGF in human RPMI-8226 cells assessed as inhibition of FGFR3 phosphorylation at 6 uM measured after 6 hrs by westernblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4838568 | B | Trapping activity at FGF in human U-266 cells assessed as inhibition of FGFR3 phosphorylation at 6 uM measured after 6 hrs by westernblot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4838569 | B | Displacement of [3H]estradiol from human full length recombinant ERalpha expressed in baculovirus-infected Sf9 cells at 5 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4838570 | B | Displacement of [3H]estradiol from human full length recombinant ERalpha expressed in baculovirus-infected Sf9 cells at 50 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 9. | ALA4838571 | B | Displacement of [3H]estradiol from human full length recombinant ERbeta expressed in baculovirus-infected Sf9 cells at 5 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4838572 | B | Displacement of [3H]estradiol from human full length recombinant ERbeta expressed in baculovirus-infected Sf9 cells at 50 uM incubated for 120 mins by radiometric scintillation counting analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4838573 | F | Antitumor activity against human KMS-11 cells xenografted in NOD-SCID mouse assessed as tumor growth inhibition at 7.5 mg/kg, ip administered every other day measured at day 17 post-tumor implantation by caliper analysis | Homo sapiens | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA4838574 | A | Total plasma concentration in NOD-SCID mouse at 7.5 mg/kg, ip measured after 90 mins by HPLC/MS/MS analysis | Mus musculus | 4 | organism-based format | Scientific Literature | ||
| 13. | ALA4838575 | B | Trapping activity at FGF in human KMS-11 cells assessed as inhibition of FGFR3 phosphorylation measured after 48 hrs by western blot analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 14. | ALA4838576 | F | Antiproliferative activity against human OPM-2 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 15. | ALA4838577 | F | Antiproliferative activity against human RPMI-8226 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4838578 | F | Antiproliferative activity against human U-266 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining-based flow cytometric analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 17. | ALA4838579 | A | Drug metabolism in NOD-SCID mouse plasma assessed as (1R)-4,4,4-trifluoro-1-((3S,10R,13S,17S)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-3-(trifluoromethyl)butane-1,3-diol formation at 7.5 mg/kg, ip measured after 90 mins by HPLC-MS/MS analysis | Mus musculus | 1 | organism-based format | Scientific Literature |
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