# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4836671 | Binding | Inhibition of CDK9 (unknown origin) using Ulight-labeled substrate measured after 1.5 hrs by TR-FRET LANCE method | Homo sapiens | 24 | ALA4834469 | single protein format | Scientific Literature | |
2. | ALA4836672 | Functional | Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability incubated for 24 hrs by Cell-Titer Glo assay | Homo sapiens | 24 | ALA4834469 | cell-based format | Scientific Literature | |
3. | ALA4836673 | Binding | Inhibition of CDK9 in human A-431 cells assessed as reduction in RNA polymerase2 phosphorylation at C-terminal ser2 residue incubated for 4 hrs by In-cell Western analysis | Homo sapiens | 23 | ALA4834469 | cell-based format | Scientific Literature | |
4. | ALA4836674 | ADME | Half life in rat at 1 mg/kg, iv | Rattus norvegicus | 14 | ALA4834469 | organism-based format | Scientific Literature | |
5. | ALA4836675 | ADME | Intrinsic clearance in rat at 1 mg/kg, iv | Rattus norvegicus | 14 | ALA4834469 | organism-based format | Scientific Literature | |
6. | ALA4836676 | ADME | Volume of distribution at steady state in rat at 1 mg/kg, iv | Rattus norvegicus | 14 | ALA4834469 | organism-based format | Scientific Literature | |
7. | ALA4836677 | ADME | AUC in rat at 1 mg/kg, po | Rattus norvegicus | 14 | ALA4834469 | organism-based format | Scientific Literature | |
8. | ALA4836678 | ADME | Oral bioavailability in rat at 1 mg/kg | Rattus norvegicus | 14 | ALA4834469 | organism-based format | Scientific Literature | |
9. | ALA4836679 | ADME | Plasma protein binding in human | Homo sapiens | 13 | ALA4834469 | cell-free format | Scientific Literature | |
10. | ALA4836680 | ADME | Plasma protein binding in rat | Rattus norvegicus | 14 | ALA4834469 | cell-free format | Scientific Literature | |
11. | ALA4836686 | Functional | Antitumor activity against human MV4-11 cells xenografted in mouse assessed as tumor growth inhibition at 15 mg/kg, po administered 2 times in a week for 3 weeks | Homo sapiens | 4 | ALA4834469 | organism-based format | Scientific Literature | |
12. | ALA4836691 | Toxicity | Toxicity in mouse xenografted with human MV4-11 cells assessed as body weight loss at 15 mg/kg, po administered 2 times in a week for 3 weeks | Mus musculus | 4 | ALA4834469 | organism-based format | Scientific Literature |