# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4843234 | Binding | Inhibition of IDO1 in mouse Panc02 cells assessed as reduction in NFK level incubated for 48 hrs by RFMS analysis | Mus musculus | 7 | ALA4842341 | cell-based format | Scientific Literature | |
2. | ALA4843237 | Binding | Inhibition of IDO1 in human HeLa cells using tryptophan as substrate incubated for 24 hrs by RFMS assay | Homo sapiens | 62 | ALA4842341 | cell-based format | Scientific Literature | |
3. | ALA4843244 | ADME | Clearance in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 7 | ALA4842341 | organism-based format | Scientific Literature | |
4. | ALA4843245 | ADME | Volume of distribution at steady state in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 7 | ALA4842341 | organism-based format | Scientific Literature | |
5. | ALA4843246 | ADME | Terminal half life in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 7 | ALA4842341 | organism-based format | Scientific Literature | |
6. | ALA4843247 | ADME | AUC (0 to infinity) in CD-1 mouse at 0.3 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 7 | ALA4842341 | organism-based format | Scientific Literature | |
7. | ALA4843248 | ADME | Cmax in CD-1 mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 7 | ALA4842341 | organism-based format | Scientific Literature | |
8. | ALA4843249 | ADME | Oral bioavailability in CD-1 mouse at 10 mg/kg measured upto 24 hrs by LC-MS/MS analysis | Mus musculus | 7 | ALA4842341 | organism-based format | Scientific Literature | |
9. | ALA4843250 | Binding | Inhibition of human ERG by fluorescence polarization assay | Homo sapiens | 6 | ALA4842341 | single protein format | Scientific Literature | |
10. | ALA4843252 | Binding | Inhibition of human ERG by Qpatch method | Homo sapiens | 3 | ALA4842341 | single protein format | Scientific Literature | |
11. | ALA4843253 | Binding | Inhibition of human ERG by manual patch clamp method | Homo sapiens | 4 | ALA4842341 | assay format | Scientific Literature | |
12. | ALA4843254 | Binding | Selectivity ratio of IC50 for inhibition of human ERG by manual patch clamp method to IC50 for inhibition of IDO1 in human HeLa cells | Homo sapiens | 10 | ALA4842341 | cell-based format | Scientific Literature | |
13. | ALA4843260 | ADME | Intrinsic clearance in rat hepatocytes | Rattus norvegicus | 1 | ALA4842341 | cell-based format | Scientific Literature | |
14. | ALA4843261 | ADME | Half life in rat hepatocytes | Rattus norvegicus | 1 | ALA4842341 | cell-based format | Scientific Literature | |
15. | ALA4843262 | ADME | Drug concentration in tumor of NSG mouse xenografted with human SKOV3 cells at 125 mg/kg, po QD administered for 5 days and measured 24 hrs post dose | Mus musculus | 8 | ALA4842341 | organism-based format | Scientific Literature | |
16. | ALA4843276 | ADME | Protein binding in human plasma at 5 uM incubated for 5 hrs by rapid equilibrium dialysis | Homo sapiens | 45 | ALA4842341 | cell-free format | Scientific Literature | |
17. | ALA4843280 | ADME | Inhibition of CYP2C9 in human liver microsomes using sulfaphenazole as substrate incubated for 10 mins in presence of NADPH by LCMS/MS analysis | Homo sapiens | 27 | ALA4842341 | microsome format | Scientific Literature | |
18. | ALA4843281 | Binding | Displacement of Tracer Red from human ERG measured after 4 hrs by fluorescence polarization assay | Homo sapiens | 32 | ALA4842341 | single protein format | Scientific Literature | |
19. | ALA4843283 | ADME | Intrinsic clearance in Beagle dog liver microsomes at 1 uM measured up to 45 mins in presence of NADPH by LC-MS/MS analysis | Canis lupus familiaris | 1 | ALA4842341 | microsome format | Scientific Literature | |
20. | ALA4843284 | ADME | Bioavailability in Beagle dog measured at 0.083 to 24 hrs by LC-MS/MS method | Canis lupus familiaris | 1 | ALA4842341 | organism-based format | Scientific Literature |