| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4815169 | F | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production at 10 uM preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess assay relative to control | Mus musculus | 90 | ALA4813945 | cell-based format | Scientific Literature | |
| 2. | ALA4815170 | F | Antiinflammatory activity against human L02 assessed as inhibition of LPS-induced NO production preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess assay relative to control | Homo sapiens | 90 | ALA4813945 | cell-based format | Scientific Literature | |
| 3. | ALA4815171 | F | Inhibition of LPS-induced NO release in mouse RAW264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay | Mus musculus | 10 | ALA4813945 | cell-based format | Scientific Literature | |
| 4. | ALA4815172 | B | Inhibition of LPS induced NO-dependent iNOS activity in mouse RAW 264.7 cells preincubated for 1 hrs followed by LPS stimulation and measured after 24 hrs by Griess reagent based assay | Mus musculus | 10 | ALA4813945 | cell-based format | Scientific Literature | |
| 5. | ALA4815173 | A | Cytotoxicity against LPS-induced mouse RAW 264.7 cells assessed as cell viability measured by MTT assay | Mus musculus | 10 | ALA4813945 | cell-based format | Scientific Literature | |
| 6. | ALA4815174 | A | Cytotoxicity against mouse RAW 264.7 cells assessed as cell viability by MTT assay | Mus musculus | 10 | ALA4813945 | cell-based format | Scientific Literature | |
| 7. | ALA4815175 | A | Cytotoxicity against human L02 cells cells assessed as cell viability by MTT assay | Homo sapiens | 10 | ALA4813945 | cell-based format | Scientific Literature | |
| 8. | ALA4815176 | F | Inhibition of LPS-induced iNOS protein expression in mouse RAW264.7 cells at 0.5 to 2 uM preincubated for 1 hrs followed by LPS-stimulation and measured after 24 hrs by Western blot analysis | Mus musculus | 1 | ALA4813945 | cell-based format | Scientific Literature | |
| 9. | ALA4815177 | B | Inhibition of iNOS dimer formation in LPS-induced mouse RAW264.7 cells at 0.5 to 2 uM preincubated for 1 hrs followed by LPS-stimulation and measured after 24 hrs by Westernblot analysis | Mus musculus | 1 | ALA4813945 | tissue-based format | Scientific Literature | |
| 10. | ALA4815178 | F | Antiinflammatory activity in complete freund's adjuvant-induced male Sprague-Dawley rat model of arthritis assessed as reduction in ankle joint swelling at 40 to 80 mg/kg, IG administered once daily for 2 to 4 weeks | Rattus norvegicus | 1 | ALA4813945 | organism-based format | Scientific Literature | |
| 11. | ALA4815179 | F | Antiinflammatory activity in complete freund's adjuvant-induced male Sprague-Dawley rat model of arthritis assessed as reduction in synovial hyperplasia at 80 mg/kg, IG after 4 weeks by H and E staining based histopathological analysis | Rattus norvegicus | 1 | ALA4813945 | organism-based format | Scientific Literature | |
| 12. | ALA4815180 | F | Antiinflammatory activity in complete freund's adjuvant-induced male Sprague-Dawley rat model of arthritis assessed as improved cartilage destruction at 80 mg/kg, IG after 4 weeks by H and E staining based histopathological analysis | Rattus norvegicus | 1 | ALA4813945 | organism-based format | Scientific Literature | |
| 13. | ALA4815181 | F | Antiinflammatory activity against freund's adjuvant-induced male Sprague-Dawley rat model of arthritis assessed as decrease INOS expression at 40 to 80, IG after 4 weeks measured by staining based immunohistochemical analysis | Rattus norvegicus | 1 | ALA4813945 | organism-based format | Scientific Literature | |
| 14. | ALA4815182 | A | Metabolic stability in human hepatocytes assessed as half life measured upto 120 mins by LC-MS/MS analysis | Homo sapiens | 6 | ALA4813945 | cell-based format | Scientific Literature | |
| 15. | ALA4815183 | A | Metabolic stability in human hepatocytes assessed as clearance incubated up to 120 mins measured per million cells by LC-MS/MS analysis | Homo sapiens | 6 | ALA4813945 | cell-based format | Scientific Literature | |
| 16. | ALA4815184 | A | Metabolic stability in human hepatocytes assessed as parent compound remaining after 120 mins by LC-MS/MS analysis | Homo sapiens | 1 | ALA4813945 | cell-based format | Scientific Literature | |
| 17. | ALA4815185 | A | Metabolic stability in rat hepatocytes assessed as half life measured upto 120 mins by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4813945 | cell-based format | Scientific Literature | |
| 18. | ALA4815186 | A | Metabolic stability in rat hepatocytes assessed as intrinsic clearance incubated up to 120 mins measured per million cells by LC-MS/MS analysis | Rattus norvegicus | 6 | ALA4813945 | cell-based format | Scientific Literature | |
| 19. | ALA4815187 | A | Metabolic stability in rat hepatocytes assessed as parent compound remaining after 120 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4813945 | cell-based format | Scientific Literature | |
| 20. | ALA4815188 | A | Inhibition of CYP1A2 in human liver microsomes using Phenacetin as substrate measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 2 | ALA4813945 | microsome format | Scientific Literature |
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