# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4832093 | F | Antiproliferative activity against human K562 cells assessed as cell growth inhibition measured after 48 hrs by CCK8 assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
2. | ALA4832094 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as degrading activity by Western blotting analysis | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
3. | ALA4832095 | A | Half life in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
4. | ALA4832096 | A | Tmax in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
5. | ALA4832097 | A | Cmax in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
6. | ALA4832098 | A | AUC (0 to t) in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
7. | ALA4832099 | A | MRT (0 to t) in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
8. | ALA4832100 | A | Apparent volume of distribution during steady state in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
9. | ALA4832101 | A | Apparent volume of distribution during terminal state in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
10. | ALA4832102 | A | Clearance in Wistar rat at 2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
11. | ALA4832103 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in Bcr-Abl level after 16 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
12. | ALA4832104 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in c-Abl level after 16 hrs by Western blotting analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4832105 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in STAT5 level after 16 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
14. | ALA4832106 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in CRLK level after 16 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
15. | ALA4832107 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in Bcr-Abl level at 30 nM by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
16. | ALA4832108 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in Bcr-Abl level at 30 nM preincubated with proteasome inhibitor MG132 for 2 hrs and measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
17. | ALA4832109 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in C-Abl level at 30 nM preincubated with proteasome inhibitor MG132 for 2 hrs and measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
18. | ALA4832110 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in Bcr-Abl level at 30 nM preincubated with NEDD8 inhibitor MLN4924 for 2 hrs and measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
19. | ALA4832111 | B | PROTAC activity at CRBN/Bcr-Abl in human K562 cells assessed as reduction in C-Abl level at 30 nM preincubated with NEDD8 inhibitor MLN4924 for 2 hrs and measured after 8 hrs by Western blotting analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
20. | ALA4832112 | B | PROTAC activity at CRBN/BCR-ABL G250E mutant in human K562 cells assessed as degradation by Western blot analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature |