| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4839297 | F | Antagonist activity at human muscarinic M2 receptor expressed in CHO cells co-expressing Gqi5 assessed as inhibition of acetylcholine-induced calcium mobilization | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
| 2. | ALA4839298 | A | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 3. | ALA4839299 | A | Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | subcellular format | Scientific Literature | ||
| 4. | ALA4839300 | A | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 5. | ALA4839301 | A | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC-MS/MS analysis | Homo sapiens | 6 | microsome format | Scientific Literature | ||
| 6. | ALA4839302 | A | Efflux ratio of apparent permeability basolateral to apical over apical to basolateral side at human P-gp in MDCK-MDR1 cells | Canis lupus familiaris | 12 | cell-based format | Scientific Literature | ||
| 7. | ALA4839303 | F | Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 8. | ALA4839304 | B | Antagonist activity at human muscarinic acetylcholine M4 receptor expressed in CHO cells assessed as inhibition of acetylcholine-induced calcium mobilization relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
| 9. | ALA4839336 | B | Selectivity index, ratio of IC50 for human muscarinic receptor M2 expressed in CHO cells to IC50 for human muscarinic receptor M4 expressed in CHO cells | Homo sapiens | 11 | cell-based format | Scientific Literature |
The page will load shortly, Thanks for your patience!