# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4808136 | Binding | PROTAC activity at CRBN/CDK12 in human Jurkat cells assessed as induction of CDK12 degradation at 100 nM incubated for 6 hrs by western blot analysis | Homo sapiens | 10 | ALA4806970 | cell-based format | Patent Bioactivity Data | |
2. | ALA4808138 | ADME | Half life in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
3. | ALA4808139 | ADME | Tmax in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
4. | ALA4808140 | ADME | Cmax in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
5. | ALA4808141 | ADME | AUClast in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
6. | ALA4808142 | ADME | AUC(infinity) in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
7. | ALA4808143 | ADME | AUC (extrapolated) in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
8. | ALA4808144 | ADME | Observed clearance in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
9. | ALA4808145 | ADME | Observed MRT (infinity) in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data | |
10. | ALA4808146 | ADME | Observed volume of distribution at steady state in C57BL/6 mouse at 2 mg/kg, iv measured up to 8 hrs post-dosing | Mus musculus | 1 | ALA4806970 | organism-based format | Patent Bioactivity Data |