| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4818405 | B | Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISA | Mus musculus | 43 | cell-based format | Scientific Literature | ||
| 2. | ALA4818407 | A | Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability at 2 hrs by CellTiter 96 AQueous One solution cell proliferation assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 3. | ALA4818408 | A | Cytotoxicity against mouse J774A.1 cells assessed as reduction in cell viability at 24 hrs by CCK8 assay | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4818409 | A | Cytotoxicity against human HEK293T cells assessed as reduction in cell viability at 24 hrs by CCK8 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4818410 | U | Selectivity index, ratio of TC50 for cytotoxicity against human HEK293T cells to IC50 for inhibition of NLRP3 in mouse J774A.1 cells | 3 | cell-based format | Scientific Literature | |||
| 6. | ALA4818411 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse J774A.1 cells assessed as inhibition of LPS and nigericin-induced IL-1beta production pre-treated for 1 hr measured after 1 hr of stimulation by ELISA | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 7. | ALA4818412 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse BMDM cells assessed as inhibition of LPS and nigericin-induced IL-1beta production pre-treated for 1 hr measured after 1 hr of stimulation by ELISA | Mus musculus | 3 | tissue-based format | Scientific Literature | ||
| 8. | ALA4818413 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse J774A.1 cells assessed as blockade of caspase 1 p20 maturation pre-treated for 1 hr measured after 1 hr of stimulation by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 9. | ALA4818414 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse J774A.1 cells assessed as blockade of IL-1beta secretion pre-treated for 1 hr measured after 1 hr of stimulation by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 10. | ALA4818415 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse J774A.1 cells assessed as effect on pro-IL-1-beta pre-treated for 1 hr at 1 to 5 uM measured after 1 hr of stimulation by Western blot analysis | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 11. | ALA4818416 | B | Inhibition of NLRP3 inflammasome activation in LPS/nigericin-treated mouse J774A.1 cells assessed as effect on ACS in cell lysate pre-treated for 1 hr at 1 to 5 uM measured after 1 hr of stimulation by Western blot analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 12. | ALA4818417 | B | Inhibition of AIM2 inflammasome activation in LPS-induced mouse J744A.1 cells infected with FLS-ST pre-treated for 1 hr at 1 to 5 uM measured after 1 hr of stimulation | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4818418 | B | Inhibition of NLRC4 inflammasome activation in LPS-induced mouse J744A.1 cells infected with FLS-ST pre-treated for 1 hr at 1 to 5 uM measured after 1 hr of stimulation | Mus musculus | 1 | tissue-based format | Scientific Literature | ||
| 14. | ALA4818419 | F | Inhibition of reactive oxygen species generation in LPS/nigericin-induced mouse J774.A1 cells pre-treated for 1 hr at 1 to 5 uM measured after 1 hr of stimulation by DCFH-DA staining-based method relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4818420 | F | Inhibition of reactive oxygen species generation in LPS/nigericin-induced mouse J774.A1 cells pre-treated for 1 hr at 1 to 5 uM measured after 1 hr of stimulation by fluorescence microplate-reader relative to control | Mus musculus | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4818421 | F | Antiinflammatory activity in po dosed LPS-induced sepsis C57BL/6 mouse model assessed as reduction in IL-1beta secretion in serum measured after 6 hrs by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4818422 | F | Antiinflammatory activity in po dosed LPS-induced sepsis C57BL/6 mouse model assessed as reduction in IL-1beta secretion in peritonial fluid measured after 6 hrs by ELISA | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4818423 | F | Anti-colitis activity against DSS-induced colitis C57BL/6 mouse model assessed as reduction in colon length treated orally once daily for 14 days started from day 3 post DSS-challenge | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4818424 | F | Anti-colitis activity against DSS-induced colitis C57BL/6 mouse model assessed as reduction in fecal occult blood treated orally once daily for 14 days started from day 3 post DSS-challenge | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4818425 | F | Anti-colitis activity against DSS-induced colitis C57BL/6 mouse model assessed as reduction in IL-1 beta in colonic tissue treated orally once daily for 14 days started from day 3 post DSS-challenge by ELISA relative to control | Mus musculus | 1 | organism-based format | Scientific Literature |
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