# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4827023 | B | Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as transcriptional activation incubated for 12 hrs by fluorescence based luciferase assay | Homo sapiens | 19 | ALA4825694 | cell-based format | Scientific Literature | |
2. | ALA4827024 | B | Partial agonist activity at GAL4 DBD-fused PPARgamma LBD (unknown origin) expressed in pG5 luc and pBIND transfected HEK293T cells assessed as maximum fold induction incubated for 12 hrs by fluorescence based luciferase assay relative to control | Homo sapiens | 19 | ALA4825694 | cell-based format | Scientific Literature | |
3. | ALA4827025 | B | Binding affinity to GAL4-DBD-fused PPARgamma ligand binding domain (unknown origin) expressed in HEK293T cells by spectra-fluorophotometry analysis | Homo sapiens | 18 | ALA4825694 | cell-based format | Scientific Literature | |
4. | ALA4827026 | A | Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition by microplate reader assay | Homo sapiens | 2 | ALA4825694 | single protein format | Scientific Literature | |
5. | ALA4827027 | F | Induction of adipogenesis in mouse 3T3-L1 cells at 1 to 5 uM measured after 48 hrs by oil-O-red staining based inverted microscopic analysis | Mus musculus | 2 | ALA4825694 | cell-based format | Scientific Literature | |
6. | ALA4827028 | F | Induction of adipogenesis in mouse 3T3-L1 cells assessed as increase in aP2 mRNA expression by qRT-PCR analysis | Mus musculus | 1 | ALA4825694 | cell-based format | Scientific Literature | |
7. | ALA4827029 | F | Induction of adipogenesis in mouse 3T3-L1 cells assessed as increase in PARPgamma mRNA expression by qRT-PCR analysis | Mus musculus | 1 | ALA4825694 | cell-based format | Scientific Literature | |
8. | ALA4827030 | F | Antidiabetic activity in high fat diet-induced obese C57/B6 mouse model assessed as reduction in glucose level at 40 mg/kg, measured after 30 days by glucose tolerance test | Mus musculus | 1 | ALA4825694 | organism-based format | Scientific Literature | |
9. | ALA4827032 | F | Hypolipidemic activity against palmitic acid-induced hyperlipidemia in human HepG2 cells assessed as increase in insulin-induced Akt Ser473 phosphorylation at 5 uM pretreated for 24 hrs followed by insulin challenge by Western blot analysis | Homo sapiens | 1 | ALA4825694 | cell-based format | Scientific Literature | |
10. | ALA4827033 | F | Hypolipidemic activity against palmitic acid-induced hyperlipidemia in human HepG2 cells assessed as increase in insulin-induced Akt thr3O8 phosphorylation at 5 uM pretreated for 24 hrs followed by insulin challenge by Western blot analysis | Homo sapiens | 1 | ALA4825694 | cell-based format | Scientific Literature | |
11. | ALA4827034 | F | Hypolipidemic activity against palmitic acid-induced hyperlipidemia in human HepG2 cells assessed as increase in insulin-induced Akt phosphorylation at 5 uM pretreated for 24 hrs followed by insulin challenge by Western blot analysis | Homo sapiens | 1 | ALA4825694 | cell-based format | Scientific Literature | |
12. | ALA4827038 | A | Induction of osteoblast differentiation in rat UMR106-06 cells assessed as reduction in mineralization measured after 48 hrs by alizarin red S staining-based method | Rattus norvegicus | 3 | ALA4825694 | cell-based format | Scientific Literature | |
13. | ALA4827039 | A | Inhibition of osteoblast differentiation in rat UMR106-06 cells assessed as reduction in alkaline phosphatase activity measured by microplate reader analysis | Rattus norvegicus | 3 | ALA4825694 | cell-based format | Scientific Literature | |
14. | ALA4827040 | A | Metabolic stability in rat liver microsomes measured after 90 mins by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825694 | microsome format | Scientific Literature | |
15. | ALA4827041 | A | Half life in rat liver microsomes measured by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825694 | microsome format | Scientific Literature | |
16. | ALA4827042 | A | Clearance in rat liver microsomes measured by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4825694 | microsome format | Scientific Literature | |
17. | ALA4827043 | A | AUC(0 to t) in Sprague-Dawley rat at 30 mg/kg, po measured up to 12 hrs by HPLC analysis | Rattus norvegicus | 1 | ALA4825694 | organism-based format | Scientific Literature | |
18. | ALA4827044 | A | AUC(0 to t) in Sprague-Dawley rat at 3 mg/kg, iv measured up to 12 hrs by HPLC analysis | Rattus norvegicus | 1 | ALA4825694 | organism-based format | Scientific Literature | |
19. | ALA4827045 | A | AUC(0 to infinity) in Sprague-Dawley rat at 30 mg/kg, po measured up to 12 hrs by HPLC analysis | Rattus norvegicus | 1 | ALA4825694 | organism-based format | Scientific Literature | |
20. | ALA4827046 | A | AUC(0 to infinity) in Sprague-Dawley rat at 3 mg/kg, iv measured up to 12 hrs by HPLC analysis | Rattus norvegicus | 1 | ALA4825694 | organism-based format | Scientific Literature |