# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835968 | B | Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as fold change in compound potentiated NMDA-induced current relative to NMDA current alone at 30 uM measured after 15 to 30 mins by patch-clamp method | Mus musculus | 61 | ALA4834434 | tissue-based format | Scientific Literature | |
2. | ALA4835982 | B | Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as potentiation of NMDA-induced current in presence of saturating glutamate by patch-clamp method | Mus musculus | 6 | ALA4834434 | tissue-based format | Scientific Literature | |
3. | ALA4835983 | B | Positive allosteric modulation of C57BL/6 mouse NMDA receptor assessed as fold change in compound potentiated NMDA-induced current relative to NMDA current alone in presence of saturating glutamate by patch-clamp method | Mus musculus | 6 | ALA4834434 | tissue-based format | Scientific Literature | |
4. | ALA4835984 | P | Brain to blood partition coefficient of the compound | 61 | ALA4834434 | tissue-based format | Scientific Literature | ||
5. | ALA4835987 | F | Antidepressant activity in ICR mouse assessed as decrease in immobility time at 30 mg/kg, ip measured after 26 mins by forced swim test | Mus musculus | 5 | ALA4834434 | organism-based format | Scientific Literature | |
6. | ALA4835988 | F | Antidepressant activity in ICR mouse assessed as decrease in immobility time at 3 to 10 mg/kg, ip measured after 26 mins by forced swim test | Mus musculus | 4 | ALA4834434 | organism-based format | Scientific Literature | |
7. | ALA4835989 | A | Effect on locomotor activity in ICR mouse assessed as hyperlocomotion at 10 mg/kg, ip measured after 90 mins | Mus musculus | 5 | ALA4834434 | organism-based format | Scientific Literature | |
8. | ALA4835990 | A | Effect on locomotor activity in ICR mouse assessed as hypolocomotion at 10 mg/kg, ip measured after 90 mins | Mus musculus | 5 | ALA4834434 | organism-based format | Scientific Literature | |
9. | ALA4835991 | F | Antidepressant activity in ICR mouse aassessed as inhibition of apomorphine-induced climbing behaviour at 10 mg/kg, ip administered prior to APO challenge and measured after 30 mins | Mus musculus | 6 | ALA4834434 | organism-based format | Scientific Literature | |
10. | ALA4836042 | A | Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition at 120 uM measured after 48 hrs by CCK8 assay relative to control | Chlorocebus sabaeus | 5 | ALA4834434 | cell-based format | Scientific Literature | |
11. | ALA4836043 | A | Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition at 60 uM measured after 48 hrs by CCK8 assay relative to control | Chlorocebus sabaeus | 5 | ALA4834434 | cell-based format | Scientific Literature | |
12. | ALA4836044 | A | Cytotoxicity against mouse L929 cells assessed as cell growth inhibition at 120 uM measured after 48 hrs by CCK8 assay relative to control | Mus musculus | 5 | ALA4834434 | cell-based format | Scientific Literature | |
13. | ALA4836045 | A | Cytotoxicity against mouse L929 cells assessed as cell growth inhibition at 60 uM measured after 48 hrs by CCK8 assay relative to control | Mus musculus | 5 | ALA4834434 | cell-based format | Scientific Literature | |
14. | ALA4836046 | A | Cytotoxicity against human HEK293 cells assessed as cell growth inhibition at 120 uM measured after 48 hrs by CCK8 assay relative to control | Homo sapiens | 5 | ALA4834434 | cell-based format | Scientific Literature | |
15. | ALA4836047 | A | Cytotoxicity against human HEK293 cells assessed as cell growth inhibition at 60 uM measured after 48 hrs by CCK8 assay relative to control | Homo sapiens | 5 | ALA4834434 | cell-based format | Scientific Literature | |
16. | ALA4836048 | B | Inhibition of human ERG expressed in CHO cells at 100 uM with holding potential at -80 to -60 mV for 500s followed by raise in potential at +30 mV for 2 sec and subsequent repolarization to -60 mV for 2 sec by whole-cell patch clamp method relative to control | Homo sapiens | 5 | ALA4834434 | cell-based format | Scientific Literature | |
17. | ALA4836049 | B | Inhibition of human ERG expressed in CHO cells at 30 uM with holding potential at -80 to -60 mV for 500s followed by raise in potential at +30 mV for 2 sec and subsequent repolarization to -60 mV for 2 sec by whole-cell patch clamp method relative to control | Homo sapiens | 5 | ALA4834434 | cell-based format | Scientific Literature |