| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4835415 | B | Agonist activity at human RXRalpha transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
| 2. | ALA4835416 | B | Agonist activity at human RXRbeta transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
| 3. | ALA4835417 | B | Agonist activity at human RXRgamma transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene assay | Homo sapiens | 39 | cell-based format | Scientific Literature | ||
| 4. | ALA4835421 | B | Agonist activity at human RXRalpha transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
| 5. | ALA4835422 | B | Agonist activity at human RXRbeta transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 41 | cell-based format | Scientific Literature | ||
| 6. | ALA4835423 | B | Agonist activity at human RXRgamma transfected in human HEK293T cells co-expressing pFR/pRL-Luc incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 32 | cell-based format | Scientific Literature | ||
| 7. | ALA4835424 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4835425 | P | Aqueous solubility of compound in pH 8 phosphate buffer incubated for 1 hr by HPLC analysis | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4835426 | F | Upregulation of ABCA1 expression in human HepG2 cells assessed as increase in mRNA expression at 1 uM incubated for 24 hrs by quantitative real-time PCR analysis relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4835427 | A | Metabolic stability in Sprague-Dawley rat liver microsomes assessed as compound degradation at 10 uM incubated for 60 min by HPLC analysis | Rattus norvegicus | 5 | microsome format | Scientific Literature | ||
| 11. | ALA4835428 | B | Agonist activity against human RARalpha in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4835429 | B | Agonist activity against human PPARalpha in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4835430 | B | Agonist activity against human PPARgamma in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA4835431 | B | Agonist activity against human PPARdelta in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4835432 | B | Agonist activity against human LXRalpha in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4835433 | B | Agonist activity against human LXRbeta in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4835434 | B | Agonist activity against human FXR in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4835435 | B | Agonist activity against human CAR in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4835436 | B | Agonist activity against human RXRalpha in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA4835437 | B | Agonist activity against human RXRbeta in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene | Homo sapiens | 3 | cell-based format | Scientific Literature |
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