# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4839488 | B | Inhibition of human full length recombinant LCK by radiometric scintillation counting analysis | Homo sapiens | 2 | ALA4837249 | single protein format | Scientific Literature | |
2. | ALA4839489 | B | Inhibition of human full length recombinant Fyn by radiometric scintillation counting analysis | Homo sapiens | 2 | ALA4837249 | single protein format | Scientific Literature | |
3. | ALA4839490 | B | Inhibition of human recombinant HCK (230 to 497) by radiometric scintillation counting analysis | Homo sapiens | 2 | ALA4837249 | single protein format | Scientific Literature | |
4. | ALA4839491 | F | Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells assessed as induction of degranulation by measuring beta-hexosaminidase release using P-nitrophenyl-N-acetyl-D-glucosamide as substrate measured after 1 hr by microplate reader | Rattus norvegicus | 20 | ALA4837249 | cell-based format | Scientific Literature | |
5. | ALA4839492 | A | Cytotoxicity against rat RBL2H3 cells assessed as cell viability incubated for 24 hrs by CCK-8 assay | Rattus norvegicus | 13 | ALA4837249 | cell-based format | Scientific Literature | |
6. | ALA4839493 | T | Therapeutic index, ratio of CC50 for rat RBL2H3 cells to IC50 for Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells | 13 | ALA4837249 | assay format | Scientific Literature | ||
7. | ALA4839494 | B | Inhibition of human recombinant CSF1R using ATP/Ulight-TK peptide incubated for 15 mins | Homo sapiens | 13 | ALA4837249 | single protein format | Scientific Literature | |
8. | ALA4839495 | F | Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells assessed as induction of degranulation by measuring beta-hexosaminidase release using P-nitrophenyl-N-acetyl-D-glucosamide as substrate at 1 uM measured after 1 hr by microplate reader relative to control | Rattus norvegicus | 36 | ALA4837249 | cell-based format | Scientific Literature | |
9. | ALA4839496 | F | Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells assessed as induction of degranulation by measuring beta-hexosaminidase release using P-nitrophenyl-N-acetyl-D-glucosamide as substrate at 0.2 uM measured after 1 hr by microplate reader relative to control | Rattus norvegicus | 36 | ALA4837249 | cell-based format | Scientific Literature | |
10. | ALA4839497 | F | Antiallergic activity against anti-DNP-IgE sensitized rat RBL-2H3 cells assessed as induction of degranulation by measuring beta-hexosaminidase release using P-nitrophenyl-N-acetyl-D-glucosamide as substrate at 0.04 uM measured after 1 hr by microplate reader relative to control | Rattus norvegicus | 36 | ALA4837249 | cell-based format | Scientific Literature | |
11. | ALA4839498 | B | Inhibition of Src phosphorylation in rat RBL-2H3 cells assessed as inhibition of Fc epsilonRI-mediated signal transduction by Western blot analysis | Rattus norvegicus | 1 | ALA4837249 | cell-based format | Scientific Literature | |
12. | ALA4839499 | B | Inhibition of Syk phosphorylation in rat RBL-2H3 cells assessed as inhibition of Fc epsilonRI-mediated signal transduction by Western blot analysis | Rattus norvegicus | 1 | ALA4837249 | cell-based format | Scientific Literature | |
13. | ALA4839500 | B | Inhibition of PLCgamma1 phosphorylation in rat RBL-2H3 cells assessed as inhibition of Fc epsilonRI-mediated signal transduction by Western blot analysis | Rattus norvegicus | 1 | ALA4837249 | cell-based format | Scientific Literature | |
14. | ALA4839501 | B | Inhibition of Akt phosphorylation in rat RBL-2H3 cells assessed as inhibition of Fc epsilonRI-mediated signal transduction by Western blot analysis | Rattus norvegicus | 1 | ALA4837249 | cell-based format | Scientific Literature | |
15. | ALA4839502 | B | Inhibition of p38 MAPK phosphorylation in rat RBL-2H3 cells assessed as inhibition of Fc epsilonRI-mediated signal transduction by Western blot analysis | Rattus norvegicus | 1 | ALA4837249 | cell-based format | Scientific Literature | |
16. | ALA4839503 | A | Half life in BALB/c mouse at 20 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4837249 | organism-based format | Scientific Literature | |
17. | ALA4839504 | A | Tmax in BALB/c mouse at 20 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4837249 | organism-based format | Scientific Literature | |
18. | ALA4839505 | A | Cmax in BALB/c mouse at 20 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4837249 | organism-based format | Scientific Literature | |
19. | ALA4839506 | A | AUC (0 to t) in BALB/c mouse at 20 mg/kg, po measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4837249 | organism-based format | Scientific Literature | |
20. | ALA4839507 | A | Clearance in BALB/c mouse at 2 mg/kg, iv measured up to 24 hrs by LC-MS/MS analysis | Mus musculus | 1 | ALA4837249 | organism-based format | Scientific Literature |