# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4809520 | Functional | Antiarrhythmic activity in patient-derived hiPSC-CMs carrying LQT3 mutation assessed as cessation dose for cell beating | Homo sapiens | 61 | ALA4808187 | tissue-based format | Scientific Literature | |
2. | ALA4809521 | Functional | Antiarrhythmic activity in patient-derived hiPSC-CMs carrying LQT3 mutation assessed as shortening of action potential duration | Homo sapiens | 61 | ALA4808187 | tissue-based format | Scientific Literature | |
3. | ALA4809522 | Functional | Antiarrhythmic activity in patient-derived hiPSC-CMs carrying LQT3 mutation assessed as fold shortening of action potential duration relative to control | Homo sapiens | 61 | ALA4808187 | tissue-based format | Scientific Literature | |
4. | ALA4809523 | Functional | Antiarrhythmic activity in patient-derived hiPSC-CMs carrying LQT3 mutation assessed as shortening dose of action potential | Homo sapiens | 61 | ALA4808187 | tissue-based format | Scientific Literature | |
5. | ALA4809524 | ADME | Antiarrhythmic activity in hiPSC-CMs assessed as cessation dose of cell beating | Homo sapiens | 61 | ALA4808187 | tissue-based format | Scientific Literature | |
6. | ALA4809525 | ADME | Antiarrhythmic activity in hiPSC-CMs assessed as dose for induction of early after depolarizations | Homo sapiens | 61 | ALA4808187 | tissue-based format | Scientific Literature | |
7. | ALA4809526 | ADME | Antiarrhythmic activity in hiPSC-CMs assessed as prolongation of action potential | Homo sapiens | 44 | ALA4808187 | tissue-based format | Scientific Literature | |
8. | ALA4809529 | Binding | Inhibition of sodium channel (unknown origin) expressed in HEK cells assessed as reduction in late inward sodium current by automated patch clamp method | Homo sapiens | 18 | ALA4808187 | cell-based format | Scientific Literature | |
9. | ALA4809530 | Binding | Inhibition of sodium channel (unknown origin) expressed in HEK cells assessed as reduction in peak sodium current by automated patch clamp method | Homo sapiens | 18 | ALA4808187 | cell-based format | Scientific Literature | |
10. | ALA4809531 | Binding | Inhibition of potassium channel (unknown origin) expressed in CHO cells assessed as reduction in potassium current by automated patch clamp method | Homo sapiens | 18 | ALA4808187 | cell-based format | Scientific Literature | |
11. | ALA4809533 | Binding | Selectivity index, ratio of IC50 for potassium channel (unknown origin) expressed in HEK cells assessed as reduction in potassium current to IC50 for sodium channel (unknown origin) expressed in HEK cells assessed as reduction in late inward sodium current | Homo sapiens | 16 | ALA4808187 | cell-based format | Scientific Literature | |
12. | ALA4809538 | Physicochemical | Chemical stability in pH 7.4 phosphate buffer assessed as half life at 100 uM by RP-HPLC analysis | 4 | ALA4808187 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4809549 | ADME | Drug metabolism assessed as human CYP3A4-mediated metabolism per ug protein | Homo sapiens | 3 | ALA4808187 | single protein format | Scientific Literature | |
14. | ALA4809550 | ADME | Drug metabolism assessed as human CYP3A5-mediated metabolism per ug protein | Homo sapiens | 3 | ALA4808187 | single protein format | Scientific Literature | |
15. | ALA4809551 | ADME | Drug metabolism assessed as human CYP2D6-mediated metabolism per ug protein | Homo sapiens | 3 | ALA4808187 | single protein format | Scientific Literature |