# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4834539 | B | Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD incubated for 60 mins by TR-FRET assay | Homo sapiens | 83 | ALA4834393 | single protein format | Scientific Literature | |
2. | ALA4834540 | B | Displacement of BODIPY FL vindoline from GST-tagged human PXR LBD at 10 uM incubated for 60 mins by TR-FRET assay relative to control | Homo sapiens | 77 | ALA4834393 | single protein format | Scientific Literature | |
3. | ALA4834541 | A | Agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by luciferase reporter assay | Homo sapiens | 83 | ALA4834393 | cell-based format | Scientific Literature | |
4. | ALA4834543 | B | Inverse agonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs by luciferase reporter assay | Homo sapiens | 83 | ALA4834393 | cell-based format | Scientific Literature | |
5. | ALA4834544 | B | Inhibition of human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter at 10 uM incubated for 24 hrs by luciferase reporter assay relative to control | Homo sapiens | 6 | ALA4834393 | cell-based format | Scientific Literature | |
6. | ALA4834545 | B | Antagonist activity at human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter incubated for 24 hrs in presence of 5 uM rifampicin by luciferase reporter assay | Homo sapiens | 83 | ALA4834393 | cell-based format | Scientific Literature | |
7. | ALA4834546 | B | Inhibition of human PXR expressed in HepG2 cells co-expressing luciferase gene under control of CYP3A4 promoter at 10 uM incubated for 24 hrs in presence of 5 uM rifampicin by luciferase reporter assay relative to control | Homo sapiens | 34 | ALA4834393 | cell-based format | Scientific Literature | |
8. | ALA5149831 | B | Induction of GSPT1 degradation in PXR knock in human SNU-C4 cells at 10 uM measured after 24 hrs by Western blot analysis relative to control | Homo sapiens | 13 | ALA5143746 | cell-based format | Scientific Literature | |
9. | ALA5149832 | B | Displacement of BODIPY FL thalidomide from 6His-tagged CRBN/DDB1 (unknown origin) expressed in baculovirus infected Sf9 insect cells incubated for 1 min under shaking condition followed by 60 mins incubation under dark condition by TR-FRET assay | Homo sapiens | 13 | ALA5143746 | cell-based format | Scientific Literature |