| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4832929 | B | Protac activity at IAP/RIPK2 in human whole blood assessed as inhibition of MDP-induced TNFalpha production by ELISA | Homo sapiens | 20 | tissue-based format | Scientific Literature | ||
| 2. | ALA4832931 | P | Lipophilicity, logD of compound at pH 7.4 by Chromatography | 20 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4832934 | A | Clearance in Wistar Han rat at 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 4. | ALA4832935 | A | Volume of distribution at steady state in Wistar Han rat at 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 5. | ALA4832936 | A | Half life in Wistar Han rat at 1 mg/kg, iv | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA4832940 | F | Ex vivo protac activity at IAP/RIPK2 in rat assessed as RIPK2 degradation at 0.5 mg/kg, sc measured for 8 to 48 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA4832941 | F | Ex vivo protac activity at IAP/RIPK2 in rat assessed as inhibition of MDP-induced TNFalpha release at 0.5 mg/kg, sc measured for 8 to 48 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 8. | ALA4832944 | B | Inhibition of full length His-tagged RIPK2 (unknown origin) expressed in baculovirus expression system using fluorescent labelled ATP competitive ligand by fluorescent polarization based binding assay | Homo sapiens | 22 | cell-based format | Scientific Literature | ||
| 9. | ALA4832945 | A | Clearance in Beagle dog at 1 mg/kg, iv measured after 2 days | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 10. | ALA4832946 | A | Half life in Beagle dog at 1 mg/kg, iv measured after 2 days | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 11. | ALA4832947 | A | Volume of distribution at steady state in Beagle dog rat at 1 mg/kg, iv measured after 2 days | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4832948 | B | Protac activity at IAP/RIPK2 in human PBMC assessed as inhibition of MDP-induced TNFalpha production incubated for 6 hrs by ELISA | Homo sapiens | 1 | tissue-based format | Scientific Literature | ||
| 13. | ALA4832949 | B | Binding affinity to human His-thr XIAP BIR2 (124 to 240) domain expressed in Escherichia coli measured after 105 mins in dark by time-resolved fluorescence laser-equipped multimode plate reader | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 14. | ALA4832950 | B | Binding affinity to human His-thr XIAP BIR3 (241 to 356) domain expressed in Escherichia coli measured after 105 mins in dark by time-resolved fluorescence laser-equipped multimode plate reader | Homo sapiens | 3 | assay format | Scientific Literature | ||
| 15. | ALA4832951 | B | Binding affinity to human 6His-thr cIAP1 BIR3 (253 to 363) domain expressed in Escherichia coli measured after 105 mins in dark by time-resolved fluorescence laser-equipped multimode plate reader | Homo sapiens | 3 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!