# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4807192 | F | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity relative to control | Homo sapiens | 50 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4807193 | F | Inhibition of GPR174 (unknown origin) in cells assessed as incorporation of nuclear localization sequence into transmembrane protein by cellular redistribution assay | Homo sapiens | 26 | assay format | Patent Bioactivity Data | ||
3. | ALA4807194 | F | Inverse agonist activity at human GPR174 expressed in cells assessed as inhibition of CRE-luc reporter activity by measuring decrease in Gs-protein signalling activity | Homo sapiens | 50 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4807196 | F | Inhibition of human GPR174 in anti-CD3/antiCD28-stimulated human PBMC assessed as increase in IL-2 level measured after 2 days by ELISA | Homo sapiens | 2 | tissue-based format | Patent Bioactivity Data | ||
5. | ALA4807223 | F | Effects of compound on IL-2 production in anti-CD3/CD28-stimulated human PBMCs assessed as increase in IL-2 level after 2 days by ELISA | Homo sapiens | 2 | tissue-based format | Patent Bioactivity Data | ||
6. | ALA4807241 | F | Induction of TNF production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in TNF level at 1 uM after 24 hrs by ELISA | Homo sapiens | 4 | tissue-based format | Patent Bioactivity Data | ||
7. | ALA4807244 | F | Induction of IL-2 production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in IL-2 level at 1 uM after 24 hrs by ELISA | Homo sapiens | 4 | tissue-based format | Patent Bioactivity Data | ||
8. | ALA4807247 | F | Induction of INF-gamma production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in INF-gamma level at 1 uM after 24 hrs by ELISA | Homo sapiens | 4 | tissue-based format | Patent Bioactivity Data | ||
9. | ALA4807261 | F | Antagonist activity at GPR174 (unknown origin) expressed in HEK293 cells assessed as inhibition of PS-induced GPR174 signaling incubated for 15 mins by GloSensor assay | Homo sapiens | 7 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4807278 | F | Inverse agonist activity at human GPR174 by CRA | Homo sapiens | 51 | assay format | Patent Bioactivity Data | ||
11. | ALA4807279 | F | Inverse agonist activity at human GPR174 assessed as fold decrease in Gs signalling activity by CRA | Homo sapiens | 51 | assay format | Patent Bioactivity Data | ||
12. | ALA4807311 | F | Induction of INF-gamma production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in INF-gamma level at 0.3 uM after 24 hrs by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
13. | ALA4807314 | F | Induction of INF-gamma production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in INF-gamma level at 1 uM after 24 hrs in presence of 0.1 uM A2aR inhibitor ZM-241385 by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
14. | ALA4807315 | F | Induction of INF-gamma production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in INF-gamma level at 0.3 uM after 24 hrs in presence of 0.1 uM A2aR inhibitor ZM-241385 by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
15. | ALA4807319 | F | Induction of IL-2 production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in IL-2 level at 0.3 uM after 24 hrs by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
16. | ALA4807322 | F | Induction of IL-2 production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in IL-2 level at 1 uM after 24 hrs in presence of 0.1 uM A2aR inhibitor ZM-241385 by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
17. | ALA4807323 | F | Induction of IL-2 production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in IL-2 level at 0.3 uM after 24 hrs in presence of 0.1 uM of A2aR inhibitor ZM-241385 by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
18. | ALA4807327 | F | Induction of TNF production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in TNF level at 0.3 uM after 24 hrs by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
19. | ALA4807330 | F | Induction of TNF production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in TNF level at 1 uM after 24 hrs in presence of 0.1 uM of A2aR inhibitor ZM-241385 by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data | ||
20. | ALA4807331 | F | Induction of TNF production in anti-CD3/CD28-stimulated human PBMCs assessed as fold increase in TNF level at 0.3 uM after 24 hrs in presence of 0.1 uM of A2aR inhibitor ZM-241385 by ELISA | Homo sapiens | 3 | tissue-based format | Patent Bioactivity Data |