# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4828020 | Binding | Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assay | Homo sapiens | 8 | ALA4825747 | cell-based format | Scientific Literature | |
2. | ALA4828021 | Binding | Antagonist activity at rat TRPA1 | Rattus norvegicus | 8 | ALA4825747 | single protein format | Scientific Literature | |
3. | ALA4828022 | Functional | In vivo antagonist activity at TRPA1 in AITC-induced rat pain model assessed as reduction in pain behaviour when administered orally | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
4. | ALA4828023 | Physicochemical | Lipophilicity, log D of the compound at pH 7.4 | 8 | ALA4825747 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4828024 | Physicochemical | Kinetic solubility of the compound | 8 | ALA4825747 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4828030 | ADME | Plasma clearance in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
7. | ALA4828031 | ADME | Unbound clearance in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
8. | ALA4828032 | ADME | Volume of distribution at steady state in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
9. | ALA4828033 | ADME | Unbound volume of distribution at steady state in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
10. | ALA4828034 | ADME | Half life in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
11. | ALA4828035 | ADME | Protein binding in human plasma incubated for 4 hrs | Homo sapiens | 8 | ALA4825747 | cell-free format | Scientific Literature | |
12. | ALA4828036 | ADME | Protein binding in rat plasma incubated for 4 hrs | Rattus norvegicus | 8 | ALA4825747 | cell-free format | Scientific Literature | |
13. | ALA4828037 | ADME | Ratio of fEC50 for in vivo antagonist activity at TRPA1 in AITC-induced rat pain model assessed as reduction in pain behaviour when administered orally to IC50 for antagonist activity at rat TRPA1 | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
14. | ALA4828038 | ADME | Permeability across apical to basolateral membrane in MDCK cells | Canis lupus familiaris | 7 | ALA4825747 | cell-based format | Scientific Literature | |
15. | ALA5055748 | ADME | Metabolic stability in human liver microsomes assessed as clearance by LC/MS-MS analysis | Homo sapiens | 16 | ALA5055619 | microsome format | Scientific Literature | |
16. | ALA5055749 | ADME | Metabolic stability in rat liver microsomes assessed as clearance by LC/MS-MS analysis | Rattus norvegicus | 16 | ALA5055619 | microsome format | Scientific Literature | |
17. | ALA5055750 | Binding | Antagonist activity at rat TRPA1 expressed in CHO cells assessed as cinnamaldehyde-induced calcium flux measured after 90 mins by FLIPR assay | Rattus norvegicus | 7 | ALA5055619 | cell-based format | Scientific Literature | |
18. | ALA5055751 | Binding | Antagonist activity at human TRPA1 expressed in CHO cells assessed as cinnamaldehyde-induced calcium flux measured after 90 mins by FLIPR assay | Homo sapiens | 21 | ALA5055619 | cell-based format | Scientific Literature | |
19. | ALA5055752 | Physicochemical | Lipophilicity, logD of compound | 21 | ALA5055619 | small-molecule physicochemical format | Scientific Literature | ||
20. | ALA5055753 | ADME | Protein binding in human plasma | Homo sapiens | 6 | ALA5055619 | cell-free format | Scientific Literature |