# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835698 | Functional | Antiproliferative activity against human RS4-11 cells assessed as growth inhibition after 72 hrs by Alamar Blue assay | Homo sapiens | 33 | ALA4834427 | cell-based format | Scientific Literature | |
2. | ALA4835759 | Binding | Molecular glue activity at CRBN/MDM2 in human RS4-11 cells assessed as induction of MDM2 degradation by measuring MDM2 level at 0.1 uM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 7 | ALA4834427 | cell-based format | Scientific Literature | |
3. | ALA4835760 | Binding | Molecular glue activity at CRBN/MDM2 in human RS4-11 cells assessed as induction of MDM2 degradation by measuring MDM2 level at 1 uM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 6 | ALA4834427 | cell-based format | Scientific Literature | |
4. | ALA4835763 | Binding | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 0.1 uM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 7 | ALA4834427 | cell-based format | Scientific Literature | |
5. | ALA4835764 | Binding | Molecular glue activity at CRBN/MDM2/p53 in human RS4-11 cells assessed as induction of p53 degradation by measuring p53 level at 1 uM incubated for 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 6 | ALA4834427 | cell-based format | Scientific Literature | |
6. | ALA4835767 | Binding | Molecular glue activity at CRBN/GSPT1 in human RS4-11 cells assessed as induction of GSPT1 degradation by measuring GSPT1 level at 0.1 uM measured after 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 7 | ALA4834427 | cell-based format | Scientific Literature | |
7. | ALA4835768 | Binding | Molecular glue activity at CRBN/GSPT1 in human RS4-11 cells assessed as induction of GSPT1 degradation by measuring GSPT1 level at 1 uM measured after 6 hrs by western blot analysis (Rvb = 100%) | Homo sapiens | 6 | ALA4834427 | cell-based format | Scientific Literature |