| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4835865 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in HBeAg secretion incubated for 24 hrs followed replacement with fresh medium and measured at day 5 post infection by ELISA | Hepatitis B virus | 41 | organism-based format | Scientific Literature | ||
| 2. | ALA4835867 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in HBeAg secretion at 111 to 1000 nM incubated for 24 hrs followed by replacement with fresh medium and measured at day 5 post infection by ELISA | Hepatitis B virus | 6 | organism-based format | Scientific Literature | ||
| 3. | ALA4835868 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in intracellular HBV RNA level at 1 uM by qPCR analysis | Hepatitis B virus | 6 | organism-based format | Scientific Literature | ||
| 4. | ALA4835869 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in intracellular accumulation of HBcAg at 1 uM by immunostaining based fluorescence microscopic analysis | Hepatitis B virus | 6 | organism-based format | Scientific Literature | ||
| 5. | ALA4835870 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in intracellular accumulation of HBsAg at 1 uM by immunostaining based fluorescence microscopic analysis | Hepatitis B virus | 6 | organism-based format | Scientific Literature | ||
| 6. | ALA4835871 | F | Antiviral activity against HDV infected in human HepG2-NTCP cells assessed as reduction in intranuclear accumulation of HDV delta antigen at 5 uM incubated for 24 hrs followed by replacement with fresh medium and measured at day 5 post infection by DAPI staining based confocal microscopic analysis (Rvb = 12.1 %) | Hepatitis delta virus | 6 | organism-based format | Scientific Literature | ||
| 7. | ALA4835873 | F | Antiviral activity against VSV infected in human HepG2-NTCP cells assessed as reduction in HBeAg and HBsAg secretion at 1 uM incubated for 24 hrs followed by replacement with fresh medium and measured at day 5 post infection by ELISA | Vesicular stomatitis virus | 6 | organism-based format | Scientific Literature | ||
| 8. | ALA4835874 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in HBeAg secretion at 1 uM preincubated with compound followed by viral infection by ELISA | Hepatitis B virus | 6 | organism-based format | Scientific Literature | ||
| 9. | ALA4835875 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in HBeAg secretion at 1 uM compound added along with viral infection by ELISA | Hepatitis B virus | 6 | organism-based format | Scientific Literature | ||
| 10. | ALA4835876 | F | Antiviral activity against HBV infected in human HepG2-NTCP cells assessed as reduction in HBeAg secretion at 1 uM pre-infected with virus followed by compound addition by ELISA | Hepatitis B virus | 6 | organism-based format | Scientific Literature | ||
| 11. | ALA4835877 | B | Inhibition of FITC-labeled HBV Pre-S1 polypeptide binding to human NTCP expressed in HepG2 cells after 2 to 3 hrs by confocal microscopic analysis | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 12. | ALA4835878 | A | Cytotoxicity against human HepG2 cells expressing NTCP assessed as reduction in cell viability at 10 uM after 48 hrs by alamar blue assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 13. | ALA4835879 | A | Cytotoxicity against primary tupaia hepatocytes expressing NTCP assessed as reduction in cell viability at 100 uM after 48 hrs by Cell-Titer Glo assay | Scandentia | 6 | cell-based format | Scientific Literature | ||
| 14. | ALA4835880 | F | Effect on NTCP surface expression in human HepG2-NTCP cells assessed as reduction in NTCP surface expression level after 2 hrs by immunostaining based assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 15. | ALA4835881 | B | Inhibition of human NTCP-mediated [3H]-TCA uptake expressed in human HepG2 cells at 2 uM | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 16. | ALA4835882 | B | Inhibition of human ASBT-mediated [3H]-TCA uptake expressed in human HepG2 cells at 2 uM | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 17. | ALA4835883 | B | Inhibition of human NTCP-mediated [3H]-Estrone sulfate uptake expressed in human HepG2 cells at 2 uM | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 18. | ALA4835884 | B | Inhibition of human OATP1B1-mediated [3H]-Estrone sulfate uptake expressed in human HepG2 cells at 2 uM | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 19. | ALA4835885 | B | Inhibition of human NTCP-mediated NQL-064 uptake expressed in human HepG2 cells incubated for 30 mins | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 20. | ALA4835886 | B | Inhibition of human NTCP-mediated NQL-065 uptake expressed in human HepG2 cells incubated for 30 mins | Homo sapiens | 4 | cell-based format | Scientific Literature |
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