| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4832570 | B | Displacement of 1,8-ANS from FABP4 (unknown origin) at 25 uM incubated for 3 mins by fluorescence based analysis relative to control | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 2. | ALA4832571 | B | Displacement of 1,8-ANS from FABP5 (unknown origin) at 25 uM incubated for 3 mins by fluorescence based analysis relative to control | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 3. | ALA4832572 | B | Displacement of 1,8-ANS from FABP4 (unknown origin) incubated for 3 mins by fluorescence based analysis | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 4. | ALA4832573 | B | Displacement of 1,8-ANS from FABP5 (unknown origin) incubated for 3 mins by fluorescence based analysis | Homo sapiens | 30 | single protein format | Scientific Literature | ||
| 5. | ALA4832574 | A | Displacement of 1,8-ANS from FABP3 (unknown origin) incubated for 3 mins by fluorescence based analysis | Homo sapiens | 5 | single protein format | Scientific Literature | ||
| 6. | ALA4832575 | B | Selectivity ratio of IC50 for FABP3 (unknown origin) to IC50 for FABP4 (unknown origin) | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 7. | ALA4832576 | B | Selectivity ratio of IC50 for FABP3 (unknown origin) to IC50 for FABP5 (unknown origin) | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 8. | ALA4832577 | A | Metabolic stability in mouse liver microsomes assessed as half life at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured for 60 mins by LC-MS/MS analysis | Mus musculus | 7 | microsome format | Scientific Literature | ||
| 9. | ALA4832578 | A | Metabolic stability in mouse liver microsomes assessed as intrinsic clearance at 0.1 uM preincubated for 10 mins followed by NADPH addition and measured for 60 mins per gm protein by LC-MS/MS analysis | Mus musculus | 7 | microsome format | Scientific Literature | ||
| 10. | ALA4832579 | A | Half life in ICR mouse at 3 mg/kg, po measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 11. | ALA4832580 | A | Half life in ICR mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA4832581 | A | Cmax in ICR mouse at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 13. | ALA4832582 | A | AUC in ICR mouse at 3 mg/kg, po measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA4832583 | A | AUC in ICR mouse at 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA4832584 | A | Clearance in ICR mouse at 3 mg/kg, po and 1 mg/kg, iv measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 16. | ALA4832585 | A | Oral bioavailability in ICR mouse at 3 mg/kg measured for 24 hrs by LC-MS/MS analysis | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 17. | ALA4832586 | A | Cytotoxicity against human THP-1 cells assessed as reduction in cell viability at 50 uM incubated for 24 hrs by CCK8 assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4832587 | F | Antiinflammatory activity against LPS-induced human THP-1 cells assessed as inhibition of MCP-1 gene expression at 25 uM incubated for 18 hrs followed by LPS-stimulation and measured after 6 hrs by qRT-PCR analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 19. | ALA4832588 | T | Toxicity in C57BL/KsJ-db/db mouse assessed as effect on body weight at 50 mg/kg, po administered for 8 weeks | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4832589 | F | Antidiabetic activity in C57BL/KsJ-db/db mouse assessed as reduction in fasting blood glucose level at 50 mg/kg, po administered for 7 weeks | Mus musculus | 3 | organism-based format | Scientific Literature |
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