# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4818605 | ADME | Cytotoxicity against human MRC-5 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay | Homo sapiens | 3 | ALA4814064 | cell-based format | Scientific Literature | |
2. | ALA4818606 | ADME | Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 72 hrs by MTS assay | Homo sapiens | 3 | ALA4814064 | cell-based format | Scientific Literature | |
3. | ALA4818607 | Binding | Inhibition of NDM-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 mins by spectrophotometric analysis | Bacteria | 43 | ALA4814064 | assay format | Scientific Literature | |
4. | ALA4818608 | Binding | Inhibition of OXA-48 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 mins by spectrophotometric analysis | Bacteria | 27 | ALA4814064 | assay format | Scientific Literature | |
5. | ALA4818609 | Binding | Inhibition of KPC-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) incubated for 3 mins by spectrophotometric analysis | Escherichia coli | 37 | ALA4814064 | assay format | Scientific Literature | |
6. | ALA4818617 | ADME | Metabolic stability in mouse liver microsomes at 5 uM after 45 min absence of NADPH by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4814064 | microsome format | Scientific Literature | |
7. | ALA4818618 | ADME | Metabolic stability in mouse liver microsomes at 5 uM assessed as intrinsic clearance measured per mg protein by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4814064 | microsome format | Scientific Literature | |
8. | ALA4818619 | Functional | Potentiation of imipenem-induced antibacterial activity against Escherichia coli clinical isolate GUE expressing NDM-1 assessed as fold change in imipenem MIC at 200 uM incubated for 18 to 24 hrs by broth microdilution method | Escherichia coli | 1 | ALA4814064 | organism-based format | Scientific Literature | |
9. | ALA4818620 | Functional | Potentiation of imipenem-induced antibacterial activity against Escherichia coli clinical isolate GUE expressing NDM-1 assessed as imipenem MIC at 20 uM incubated for 18 to 24 hrs by broth microdilution method (Rvb = 16 ug/ml) | Escherichia coli | 3 | ALA4814064 | organism-based format | Scientific Literature | |
10. | ALA4818621 | Functional | Potentiation of imipenem-induced antibacterial activity against Escherichia coli clinical isolate GUE expressing NDM-1 assessed as imipenem MIC at 50 uM incubated for 18 to 24 hrs by broth microdilution method (Rvb = 16 ug/ml) | Escherichia coli | 3 | ALA4814064 | organism-based format | Scientific Literature | |
11. | ALA4818622 | Functional | Potentiation of imipenem-induced antibacterial activity against Escherichia coli clinical isolate GUE expressing NDM-1 assessed as imipenem MIC at 100 uM incubated for 18 to 24 hrs by broth microdilution method (Rvb = 16 ug/ml) | Escherichia coli | 3 | ALA4814064 | organism-based format | Scientific Literature | |
12. | ALA4818623 | Binding | Inhibition of NDM-1 (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM incubated for 3 mins by spectrophotometric analysis relative to control | Bacteria | 40 | ALA4814064 | assay format | Scientific Literature | |
13. | ALA4818624 | Binding | Inhibition of OXA-48 (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM incubated for 3 mins by spectrophotometric analysis relative to control | Bacteria | 28 | ALA4814064 | assay format | Scientific Literature | |
14. | ALA4818625 | Binding | Inhibition of KPC-2 (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM incubated for 3 mins by spectrophotometric analysis relative to control | Escherichia coli | 31 | ALA4814064 | assay format | Scientific Literature |