# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4825025 | B | Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 residues) expressed in Rosetta-Gami B(DE3) cells by isothermal titration calorimetry | Homo sapiens | 35 | ALA4823296 | cell-based format | Scientific Literature | |
2. | ALA4825026 | B | Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 residues) expressed in Rosetta-Gami B(DE3) cells assessed as change in chemical shift perturbation at Met 164 residues at 40 uM by 2D-[13C-1H] HSQC NMR spectroscopy | Homo sapiens | 35 | ALA4823296 | cell-based format | Scientific Literature | |
3. | ALA4825027 | B | Binding affinity to N-terminal His tagged EphA3 LBD (unknown origin) expressed in Rosetta-Gami B(DE3) cells by isothermal titration calorimetry | Homo sapiens | 6 | ALA4823296 | cell-based format | Scientific Literature | |
4. | ALA4825028 | B | Binding affinity to N-terminal His tagged EphA2 LBD (27 to 200 residues) (unknown origin) expressed in Origami (DE3) cells by isothermal titration calorimetry | Homo sapiens | 6 | ALA4823296 | cell-based format | Scientific Literature | |
5. | ALA4825029 | P | Aqueous solubility of compound | 6 | ALA4823296 | small-molecule physicochemical format | Scientific Literature | ||
6. | ALA4825030 | B | Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 residues) expressed in Rosetta-Gami B(DE3) cells assessed as change in chemical shift perturbation at Met 115 residues at 40 uM by 2D-[13C-1H] HSQC NMR spectroscopy | Homo sapiens | 6 | ALA4823296 | cell-based format | Scientific Literature | |
7. | ALA4825031 | B | Binding affinity to N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 residues) expressed in Rosetta-Gami B(DE3) cells assessed as change in chemical shift perturbation at Met 60 residues at 40 uM by 2D-[13C-1H] HSQC NMR spectroscopy | Homo sapiens | 6 | ALA4823296 | cell-based format | Scientific Literature | |
8. | ALA4825032 | B | Displacement of EphrinA5 from N-terminal His tagged EphA4 LBD (unknown origin) (29 to 209 residues) expressed in Rosetta-Gami B(DE3) cells by 2D-[13C-1H] HSQC NMR spectroscopy | Homo sapiens | 1 | ALA4823296 | cell-based format | Scientific Literature | |
9. | ALA4825033 | B | Agonist activity at EphA4 in B6-Cg-Tg(Hlxb9-GFP)1Tmj/J (Hb9-GFP) mouse primary spinal cord motor neuron cells assessed as protein phosphorylation at Y20 residues at 1 to 10 uM incubated for 30 mins by Western blotting analysis | Mus musculus | 1 | ALA4823296 | assay format | Scientific Literature | |
10. | ALA4825034 | B | Agonist activity at EphA4 in B6-Cg-Tg(Hlxb9-GFP)1Tmj/J (Hb9-GFP) mouse spinal cord motor neurons assessed as induction of growth cone collapse at 1 to 10 uM by rhodamine-coupled phalloidin dye based inverted fluorescent microscopic method | Mus musculus | 1 | ALA4823296 | single protein format | Scientific Literature | |
11. | ALA4825035 | B | Agonist activity at EphA4 in B6-Cg-Tg(Hlxb9-GFP)1Tmj/J (Hb9-GFP) mouse spinal cord motor neurons assessed as induction of growth cone collapse at 1 to 10 uM in presence of ephrin A1-Fc by rhodamine-coupled phalloidin dye based inverted fluorescent microscopic method | Mus musculus | 1 | ALA4823296 | single protein format | Scientific Literature | |
12. | ALA4825036 | F | Cytoprotective activity against patient derived induced astrocyte-mediated B6-Cg-Tg(Hlxb9-GFP)1Tmj/J (Hb9-GFP) mouse motor neuron death at 10 uM measured after 3 days by imaging method | Mus musculus | 1 | ALA4823296 | tissue-based format | Scientific Literature |