| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4828020 | Binding | Antagonist activity at human TRPA1 expressed in CHO cells measured by calcium based FLIPR assay | Homo sapiens | 8 | ALA4825747 | cell-based format | Scientific Literature | |
| 2. | ALA4828021 | Binding | Antagonist activity at rat TRPA1 | Rattus norvegicus | 8 | ALA4825747 | single protein format | Scientific Literature | |
| 3. | ALA4828022 | Functional | In vivo antagonist activity at TRPA1 in AITC-induced rat pain model assessed as reduction in pain behaviour when administered orally | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
| 4. | ALA4828023 | Physicochemical | Lipophilicity, log D of the compound at pH 7.4 | 8 | ALA4825747 | small-molecule physicochemical format | Scientific Literature | ||
| 5. | ALA4828024 | Physicochemical | Kinetic solubility of the compound | 8 | ALA4825747 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4828030 | ADME | Plasma clearance in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
| 7. | ALA4828031 | ADME | Unbound clearance in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
| 8. | ALA4828032 | ADME | Volume of distribution at steady state in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
| 9. | ALA4828033 | ADME | Unbound volume of distribution at steady state in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
| 10. | ALA4828034 | ADME | Half life in rat at 1 mg/kg | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
| 11. | ALA4828035 | ADME | Protein binding in human plasma incubated for 4 hrs | Homo sapiens | 8 | ALA4825747 | cell-free format | Scientific Literature | |
| 12. | ALA4828036 | ADME | Protein binding in rat plasma incubated for 4 hrs | Rattus norvegicus | 8 | ALA4825747 | cell-free format | Scientific Literature | |
| 13. | ALA4828037 | ADME | Ratio of fEC50 for in vivo antagonist activity at TRPA1 in AITC-induced rat pain model assessed as reduction in pain behaviour when administered orally to IC50 for antagonist activity at rat TRPA1 | Rattus norvegicus | 6 | ALA4825747 | organism-based format | Scientific Literature | |
| 14. | ALA4828038 | ADME | Permeability across apical to basolateral membrane in MDCK cells | Canis lupus familiaris | 7 | ALA4825747 | cell-based format | Scientific Literature |
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