# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4832674 | Binding | Inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured at second inhibition step by fluorometric enzyme assays | Trypanosoma brucei | 29 | ALA4831511 | single protein format | Scientific Literature | |
2. | ALA4832676 | Binding | Inhibition of human liver CatL assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate measured at second inhibition step by fluorometric enzyme assays | Homo sapiens | 26 | ALA4831511 | tissue-based format | Scientific Literature | |
3. | ALA4832679 | Toxicity | Selectivity index, ratio of Ki for human liver CatL to Trypanosoma brucei rhodesain | 14 | ALA4831511 | assay format | Scientific Literature | ||
4. | ALA4832680 | Binding | Inhibition of human liver CatB assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate at 11 uM by fluorometric enzyme assays | Homo sapiens | 6 | ALA4831511 | tissue-based format | Scientific Literature | |
5. | ALA4832681 | Binding | Reversible inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate by fluorometric enzyme assays | Trypanosoma brucei | 2 | ALA4831511 | single protein format | Scientific Literature | |
6. | ALA4832682 | Binding | Competitive inhibition of Trypanosoma brucei rhodesain assessed as fluorescence using Cbz-Phe-Arg-AMC as substrate by fluorometric enzyme assays | Trypanosoma brucei | 2 | ALA4831511 | single protein format | Scientific Literature | |
7. | ALA4832685 | Binding | Reversible inhibition of Trypanosoma brucei rhodesain assessed as reversibility using Cbz-Phe-Arg-AMC as substrate by dilution assay | Trypanosoma brucei | 2 | ALA4831511 | single protein format | Scientific Literature | |
8. | ALA4832686 | Binding | Reversible inhibition of Trypanosoma brucei rhodesain assessed as reversibility by measuring residual enzymatic activity using Cbz-Phe-Arg-AMC as substrate after 1 hr by fluorometry based dialysis experiment relative to control | Trypanosoma brucei | 3 | ALA4831511 | single protein format | Scientific Literature | |
9. | ALA4832689 | Functional | Antiprotozoal activity against Trypanosoma brucei brucei TC211 assessed as luminescence incubated for 24 to 48 hrs by ATPlite assay | Trypanosoma brucei brucei | 4 | ALA4831511 | organism-based format | Scientific Literature | |
10. | ALA4832690 | Functional | Cytotoxicity against mouse J774.1 cells by Alamar blue assay | Mus musculus | 11 | ALA4831511 | cell-based format | Scientific Literature | |
11. | ALA4832691 | Functional | Cytotoxicity against human HeLa cells by Alamar blue assay | Homo sapiens | 11 | ALA4831511 | cell-based format | Scientific Literature | |
12. | ALA4832692 | Binding | Inhibition of trypsin-like activity of human 20S proteasome at 11 uM using boc-Leu-Arg-Arg-AMC as fluorogenic substrate by microplate reader relative to control | Homo sapiens | 10 | ALA4831511 | single protein format | Scientific Literature | |
13. | ALA4832693 | Binding | Inhibition of caspase-like activity of human 20S proteasome at 11 uM using Cbz-Leu-Leu-Glu-AMC as fluorogenic substrate by microplate reader relative to control | Homo sapiens | 10 | ALA4831511 | assay format | Scientific Literature | |
14. | ALA4832694 | Binding | Inhibition of alpha-chymotrypsin-like activity of human 20S proteasome at 11 uM using Succ-Leu-Leu-Val-Tyr-AMC as fluorogenic substrate by microplate reader relative to control | Homo sapiens | 10 | ALA4831511 | assay format | Scientific Literature | |
15. | ALA4832695 | Binding | Inhibition of Dengue virus NS2B-NS3 protease assessed as fluorescent emission using boc-Gly-Arg-Arg-AMC at 11 uM by microplate reader relative to control | Dengue virus | 10 | ALA4831511 | assay format | Scientific Literature |