# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4831075 | A | Drug metabolism in human MDA-MB-231 cells assessed as increase of free amonafide in cell at 25 uM measured after 2 hrs by fluorescence based microscopic assay | Homo sapiens | 1 | ALA4828759 | cell-based format | Scientific Literature | |
2. | ALA4831076 | A | Drug metabolism in human MDA-MB-231 cells xenografted in athymic Balb/c mouse assessed as increase of free amonafide in tumor at 10 mg/kg, ip measured after 120 hrs by fluorescence based microscopic assay | Homo sapiens | 1 | ALA4828759 | organism-based format | Scientific Literature | |
3. | ALA4831077 | A | Accumulation half life in tumor of athymic Balb/c mouse xenografted with human MDA-MB-231 cells at 10 mg/kg, ip | Mus musculus | 1 | ALA4828759 | organism-based format | Scientific Literature | |
4. | ALA4831078 | B | Inhibition of DNA Topoisomerase-2 in human MDA-MB-238 cells assessed as generation of DNA double strand breaks by measuring gamma-H2AX at 2 uM incubated for 24 hrs followed by drug washout and measured after 24 hrs by immunofluorescence assay | Homo sapiens | 2 | ALA4828759 | cell-based format | Scientific Literature | |
5. | ALA4831079 | B | Inhibition of DNA Topoisomerase-2 in human MDA-MB-238 cells assessed as generation of DNA double strand breaks measuring gamma-H2AX at 2 uM incubated for 24 hrs followed by drug washout and measured after 96 hrs by immunofluorescence assay | Homo sapiens | 2 | ALA4828759 | cell-based format | Scientific Literature | |
6. | ALA4831081 | F | Cytotoxicity against human A 172 cells assessed as cell viability measured after 96 hrs by XTT assay | Homo sapiens | 5 | ALA4828759 | cell-based format | Scientific Literature | |
7. | ALA4831082 | F | Cytotoxicity against human WM 266-4 cells assessed as cell viability measured after 96 hrs by XTT assay | Homo sapiens | 5 | ALA4828759 | cell-based format | Scientific Literature | |
8. | ALA4831083 | F | Cytotoxicity against human NCI-H1299 cells assessed as cell viability measured after 96 hrs by XTT assay | Homo sapiens | 5 | ALA4828759 | cell-based format | Scientific Literature | |
9. | ALA4831084 | F | Cytotoxicity against human MDA-MB-238 cells assessed as cell viability measured after 96 hrs by XTT assay | Homo sapiens | 5 | ALA4828759 | cell-based format | Scientific Literature | |
10. | ALA4831085 | F | Antitumour activity against human MDA-MB-238 cells xenografted in athymic nude-Foxn 1nu mouse assessed as inhibition of tumour growth at 1.9 mg/kg, ip measured after 5 weeks | Homo sapiens | 2 | ALA4828759 | organism-based format | Scientific Literature | |
11. | ALA4831086 | F | Antitumour activity against human MDA-MB-238 cells xenografted in athymic nude-Foxn 1nu mouse assessed as inhibition of tumour growth at 3.8 mg/kg, ip measured after 5 weeks | Homo sapiens | 1 | ALA4828759 | organism-based format | Scientific Literature |