# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4825891 | A | Protein binding in rat plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Rattus norvegicus | 12 | cell-free format | Scientific Literature | ||
2. | ALA4825892 | A | Protein binding in dog plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Canis lupus familiaris | 12 | cell-free format | Scientific Literature | ||
3. | ALA4825893 | A | Protein binding in human plasma assessed as unbound fraction at 5 uM by LC-MS/MS analysis based equilibrium dialysis method | Homo sapiens | 12 | cell-free format | Scientific Literature | ||
4. | ALA4825894 | A | Intrinsic clearance in Sprague-Dawley rat liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 12 | microsome format | Scientific Literature | ||
5. | ALA4825895 | A | Intrinsic clearance in Beagle dog liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Canis lupus familiaris | 12 | microsome format | Scientific Literature | ||
6. | ALA4825896 | A | Intrinsic clearance in human liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 12 | microsome format | Scientific Literature | ||
7. | ALA4825897 | A | Half life in Sprague-Dawley rat liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Rattus norvegicus | 9 | microsome format | Scientific Literature | ||
8. | ALA4825898 | A | Half life in Beagle dog liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Canis lupus familiaris | 9 | microsome format | Scientific Literature | ||
9. | ALA4825899 | A | Half life in human liver microsomes preincubated followed by NADPH addition and measured up to 45 mins by LC-MS/MS analysis | Homo sapiens | 9 | microsome format | Scientific Literature | ||
10. | ALA4825900 | A | Cmax in CD1 mouse at 5 mg/kg, po measured after 0.03 to 24 hrs by UHPLC-TOF method | Mus musculus | 2 | organism-based format | Scientific Literature | ||
11. | ALA4825901 | A | Clearance in CD1 mouse at 1 mg/kg, iv measured after 0.083 to 24 hrs by UHPLC-TOF method | Mus musculus | 6 | organism-based format | Scientific Literature | ||
12. | ALA4825902 | A | Volume of distribution at steady state in CD1 mouse at 1 mg/kg, iv measured after 0.083 to 24 hrs by UHPLC-TOF method | Mus musculus | 5 | organism-based format | Scientific Literature | ||
13. | ALA4825903 | A | Oral bioavailability in CD1 mouse at 5 mg/kg measured after 0.03 to 24 hrs by UHPLC-TOF method | Mus musculus | 2 | organism-based format | Scientific Literature | ||
14. | ALA4825906 | B | Inhibition of Respiratory syncytial virus A2 fusion protein expressed in HEK293T cells harboring GAL4-NF-kappaB assessed as reduction in cell-cell fusion by luciferase assay | Human respiratory syncytial virus A2 | 24 | cell-based format | Scientific Literature | ||
15. | ALA4825907 | P | Thermodynamic solubility in PBS at 1 to 100 uM at pH 7.4 by HPLC-UV method | 11 | small-molecule physicochemical format | Scientific Literature | |||
16. | ALA4825908 | A | Apparent permeability across apical to basolateral side in MDCK-MDR1 cells at 10 uM measured at 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 9 | cell-based format | Scientific Literature | ||
17. | ALA4825909 | A | Apparent permeability across basolateral side to apical side in MDCK-MDR1 cells at 10 uM measured at 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 9 | cell-based format | Scientific Literature | ||
18. | ALA4825910 | A | Efflux ratio of apparent permeability in MDCK-MDR1 cells at 10 uM measured at 60 mins by LC-MS/MS analysis | Canis lupus familiaris | 9 | cell-based format | Scientific Literature | ||
19. | ALA4825912 | A | Cmax in Sprague-Dawley rat at 5 mg/kg, po administered via gavage measured after 0.02 to 24 hrs by tandem liquid chromatography/mass spectrometry | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
20. | ALA4825913 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv administered via gavage measured after 0.02 to 24 hrs by tandem liquid chromatography/mass spectrometry | Rattus norvegicus | 5 | organism-based format | Scientific Literature |