# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4819826 | Binding | Modulation of Myc-Nur77 (unknown origin) transfected in human HEK293T cells assessed as induction of Myc-Nur77 mitochondrial targeting by measuring increase in Myc-Nur77 accumulation in mitochondria at 0.5 uM measured after 2 hrs by western blot analysis | Homo sapiens | 2 | ALA4819003 | mitochondrion format | Scientific Literature | |
2. | ALA4819827 | Binding | Modulation of Myc-Nur77 (unknown origin) transfected in human HEK293T cells co-transfected with Flag-tagged Bcl2 assessed as interaction of Nur77 with Bcl2 at 0.5 uM measured after 1 to 3 hrs by co-immunoprecipitation assay | Homo sapiens | 1 | ALA4819003 | cell-based format | Scientific Literature | |
3. | ALA4819828 | Functional | Induction of apoptosis in human MDA-MB-231 cells assessed as PARP cleavage at 0.5 uM measured after 6 hrs by western blot assay | Homo sapiens | 39 | ALA4819003 | cell-based format | Scientific Literature | |
4. | ALA4819829 | Functional | Induction of apoptosis in human HCT-116 cells assessed as PARP cleavage at 0.5 uM measured after 6 hrs by western blot assay | Homo sapiens | 39 | ALA4819003 | cell-based format | Scientific Literature | |
5. | ALA4819830 | Functional | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4819003 | cell-based format | Scientific Literature | |
6. | ALA4819831 | Functional | Cytotoxicity against human BT-549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4819003 | cell-based format | Scientific Literature | |
7. | ALA4819832 | ADME | Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4819003 | cell-based format | Scientific Literature | |
8. | ALA4819833 | Functional | Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4819003 | cell-based format | Scientific Literature | |
9. | ALA4819834 | Functional | Cytotoxicity against human SW-620 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4819003 | cell-based format | Scientific Literature | |
10. | ALA4819835 | ADME | Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay | Homo sapiens | 7 | ALA4819003 | cell-based format | Scientific Literature | |
11. | ALA4819836 | Functional | Induction of apoptosis in human MDA-MB-231 cells assessed as PARP cleavage at 0.5 uM measured after 6 hrs by western blot assay relative to Di(1H-indol-3-yl)(4-(trifluoromethyl)phenyl)methylium methanesulfonate | Homo sapiens | 3 | ALA4819003 | cell-based format | Scientific Literature | |
12. | ALA4819837 | Functional | Induction of apoptosis in human HCT-116 cells assessed as PARP cleavage at 0.5 uM measured after 6 hrs by western blot assay relative to Di(1H-indol-3-yl)(4-(trifluoromethyl)phenyl)methylium methanesulfonate | Homo sapiens | 1 | ALA4819003 | cell-based format | Scientific Literature | |
13. | ALA4819838 | Functional | Induction of apoptosis in human BT-549 cells assessed as PARP cleavage at 0.5 uM measured after 6 hrs by western blot assay | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature | |
14. | ALA4819839 | Functional | Induction of apoptosis in human SW-620 cells assessed as PARP cleavage at 0.5 uM measured after 6 hrs by western blot assay | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature | |
15. | ALA4819840 | Functional | Induction of apoptosis in human MDA-MB-231 cells assessed as viable cells at 0.5 uM measured after 6 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 98.51%) | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature | |
16. | ALA4819841 | Functional | Induction of apoptosis in human MDA-MB-231 cells assessed as early apoptotic cells at 0.5 uM measured after 6 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 1.27%) | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature | |
17. | ALA4819842 | Functional | Induction of apoptosis in human MDA-MB-231 cells assessed as late apoptotic cells at 0.5 uM measured after 6 hrs by Annexin V-FITC/PI staining based flowcytometry method (Rvb = 0.11%) | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature | |
18. | ALA4819843 | Functional | Induction of apoptosis in human MDA-MB-231 cells assessed as necrotic cells at 0.5 uM measured after 6 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 0.11%) | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature | |
19. | ALA4819844 | Functional | Induction of apoptosis in human BT-549 cells assessed as viable cells at 0.5 uM measured after 6 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 98.51%) | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature | |
20. | ALA4819845 | Functional | Induction of apoptosis in human BT-549 cells assessed as early apoptotic cells at 0.5 uM measured after 6 hrs by Annexin V-FITC/PI staining based flow cytometry method (Rvb = 1.27%) | Homo sapiens | 2 | ALA4819003 | cell-based format | Scientific Literature |