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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4840616 Binding Inhibition of serotonin transporter expressed in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake measured after 15 mins by scintillation counting analysis Rattus norvegicus 23 ALA4840307 tissue-based format Scientific Literature 2. ALA4840617 ADME Metabolic stability in rat liver microsomes assessed as half life incubated for 60 mins by LC-MS/MS analysis Rattus norvegicus 4 ALA4840307 microsome format Scientific Literature 3. ALA4840618 ADME Metabolic stability in rat liver microsomes assessed as clearance incubated for 60 mins by LC-MS/MS analysis Rattus norvegicus 4 ALA4840307 microsome format Scientific Literature 4. ALA4840619 ADME Cmax in Sprague-Dawley rat at 2 mg/kg, iv measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 5. ALA4840620 ADME Cmax in Sprague-Dawley rat at 5 mg/kg, po measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 6. ALA4840621 ADME AUC (0 to t) in Sprague-Dawley rat at 2 mg/kg, iv measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 7. ALA4840622 ADME AUC (0 to t) in Sprague-Dawley rat at 5 mg/kg, po measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 8. ALA4840623 ADME Half life in Sprague-Dawley rat at 2 mg/kg, iv measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 9. ALA4840624 ADME Half life in Sprague-Dawley rat at 5 mg/kg, po measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 10. ALA4840625 ADME Volume of distribution in steady state in Sprague-Dawley rat at 2 mg/kg, iv measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 11. ALA4840626 ADME Clearance in Sprague-Dawley rat at 2 mg/kg, iv measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 12. ALA4840627 ADME Oral bioavailability in Sprague-Dawley rat at 5 mg/kg measured by LC-MS/MS analysis Rattus norvegicus 2 ALA4840307 organism-based format Scientific Literature 13. ALA4840628 Binding Antagonist activity at SERT in Sprague-Dawley rat hypothalamus assessed as PCA induced serotonin depletion at 10 mg/kg, iv measured after 30 mins by LC-MS/MS analysis Rattus norvegicus 1 ALA4840307 organism-based format Scientific Literature 14. ALA4840629 Functional Antidepressant-like activity in rat assessed as reduction in immobility time at 3 ml/kg, sc measured after 60 mins by Forced swimming test Rattus norvegicus 1 ALA4840307 organism-based format Scientific Literature 15. ALA4840630 Functional Antidepressant-like activity in rat assessed as reduction in immobility time at 10 ml/kg, sc measured after 60 mins by Forced swimming test Rattus norvegicus 1 ALA4840307 organism-based format Scientific Literature 16. ALA4840631 Binding Inhibition of 5-HT1a (unknown origin) Homo sapiens 4 ALA4840307 single protein format Scientific Literature 17. ALA4840632 Binding Inhibition of 5-HT2a (unknown origin) Homo sapiens 3 ALA4840307 single protein format Scientific Literature 18. ALA4840633 Binding Inhibition of 5-HT2c (unknown origin) Homo sapiens 3 ALA4840307 single protein format Scientific Literature 19. ALA4840634 Binding Inhibition of 5-HT3 (unknown origin) Homo sapiens 3 ALA4840307 single protein format Scientific Literature