# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4822088 | ADME | Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by colorimetric analysis | Ovis aries | 16 | ALA4819098 | single protein format | Scientific Literature | |
2. | ALA4822089 | Binding | Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by colorimetric analysis | Homo sapiens | 16 | ALA4819098 | single protein format | Scientific Literature | |
3. | ALA4822090 | Binding | Selectivity index, ratio of IC50 for ovine COX-1 to IC50 for human recombinant COX-2 | 16 | ALA4819098 | assay format | Scientific Literature | ||
4. | ALA4822091 | Binding | Inhibition of soybean 15-LOX using arachidonic acid or linolenic acid as substrate in presence of hydrogen peroxide incubated for 5 mins by colorimetric analysis | Glycine max | 15 | ALA4819098 | assay format | Scientific Literature | |
5. | ALA4822092 | Functional | Inhibition of LPS-induced NO production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by DAF-FM based fluorescence analysis | Mus musculus | 16 | ALA4819098 | cell-based format | Scientific Literature | |
6. | ALA4822093 | Functional | Antioxidant activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced intracellular ROS production preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by DCFH-DA staining based fluorescence analysis | Mus musculus | 16 | ALA4819098 | cell-based format | Scientific Literature | |
7. | ALA4822094 | Functional | Inhibition of LPS-induced TNFalpha production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA | Mus musculus | 16 | ALA4819098 | cell-based format | Scientific Literature | |
8. | ALA4822095 | Functional | Inhibition of LPS-induced IL-6 production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA | Mus musculus | 16 | ALA4819098 | cell-based format | Scientific Literature | |
9. | ALA4822096 | Functional | Inhibition of LPS-induced 15(S)-HETE production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA | Mus musculus | 16 | ALA4819098 | cell-based format | Scientific Literature | |
10. | ALA4822097 | Binding | Potency index, ratio of diclofenac sodium IC50 to test compound IC50 for human recombinant COX-2 using arachidonic acid as substrate preincubated with enzyme for 5 mins followed by substrate addition by colorimetric analysis | Homo sapiens | 14 | ALA4819098 | single protein format | Scientific Literature | |
11. | ALA4822100 | Functional | Potency index, ratio of celecoxib IC50 to test compound IC50 for antioxidant activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced intracellular ROS production preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by DCFH-DA staining based fluorescence analysis | Mus musculus | 1 | ALA4819098 | cell-based format | Scientific Literature | |
12. | ALA4822101 | ADME | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability by MTS assay | Mus musculus | 14 | ALA4819098 | cell-based format | Scientific Literature | |
13. | ALA4822105 | Functional | Potency index, ratio of celecoxib IC50 to test compound IC50 for inhibition of LPS-induced IL-6 production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA | Mus musculus | 6 | ALA4819098 | cell-based format | Scientific Literature | |
14. | ALA4822106 | Functional | Potency index, ratio of diclofenac sodium IC50 to test compound IC50 for inhibition of LPS-induced IL-6 production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA | Mus musculus | 6 | ALA4819098 | cell-based format | Scientific Literature | |
15. | ALA4822107 | Functional | Potency index, ratio of celecoxib IC50 to test compound IC50 for inhibition of LPS-induced 15(S)-HETE production in mouse RAW264.7 cells preincubated for 2 hrs followed by LPS stimulation and measured after 20 hrs by ELISA | Mus musculus | 1 | ALA4819098 | cell-based format | Scientific Literature |