# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4808633 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 24 | ALA4808171 | cell-based format | Scientific Literature | |
2. | ALA4808637 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE (Gq) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 3 | ALA4808171 | cell-based format | Scientific Literature | |
3. | ALA4808638 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 3 | ALA4808171 | cell-based format | Scientific Literature | |
4. | ALA4808639 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE (G12/13) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 1 | ALA4808171 | cell-based format | Scientific Literature | |
5. | ALA4808642 | F | Agonist activity at GPR40 in mouse MIN6 cells assessed as fold increase in 17 mM glucose-mediated insulin secretion at 1 to 10 uM incubated for 2 hrs in presence of GW1100 by ELISA relative to control | Mus musculus | 3 | ALA4808171 | cell-based format | Scientific Literature | |
6. | ALA4808643 | F | Agonist activity at GPR40 in mouse MIN6 cells assessed as fold increase in 3 mM glucose-mediated insulin secretion at 10 uM incubated for 2 hrs by ELISA relative to control | Mus musculus | 3 | ALA4808171 | cell-based format | Scientific Literature | |
7. | ALA4808679 | F | Antidiabetic activity in C57BL/6J mouse assessed as reduction in plasma glucose level at 10 mg/kg, po pretreated 1 hr before glucose challenge measured up to 120 mins by Oral glucose tolerance test | Mus musculus | 1 | ALA4808171 | organism-based format | Scientific Literature | |
8. | ALA4808681 | F | Antidiabetic activity in C57BL/6J mouse assessed as increase in plasma GLP1 level at 10 mg/kg, po measured after 30 mins by ELISA relative control | Mus musculus | 1 | ALA4808171 | organism-based format | Scientific Literature | |
9. | ALA4808683 | F | Antidiabetic activity in C57BL/6J mouse assessed as increase in plasma GLP1 level at 10 mg/kg, po measured after 30 mins in presence of KR-62436 by ELISA relative to KR-62436 treated control | Mus musculus | 1 | ALA4808171 | organism-based format | Scientific Literature |