| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4808633 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE assessed as firefly luciferase activity incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 24 | cell-based format | Scientific Literature | ||
| 2. | ALA4808637 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE (Gq) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4808638 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/CRE (Gs) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4808639 | F | Agonist activity at GPR40 (unknown origin) expressed in CHO cells co-expressing luc2P/SRE (G12/13) assessed as firefly luciferase activity at 10 uM incubated for 24 hrs by Bright-Glo based serum response element (SRE) luciferase reporter assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4808642 | F | Agonist activity at GPR40 in mouse MIN6 cells assessed as fold increase in 17 mM glucose-mediated insulin secretion at 1 to 10 uM incubated for 2 hrs in presence of GW1100 by ELISA relative to control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 6. | ALA4808643 | F | Agonist activity at GPR40 in mouse MIN6 cells assessed as fold increase in 3 mM glucose-mediated insulin secretion at 10 uM incubated for 2 hrs by ELISA relative to control | Mus musculus | 3 | cell-based format | Scientific Literature | ||
| 7. | ALA4808679 | F | Antidiabetic activity in C57BL/6J mouse assessed as reduction in plasma glucose level at 10 mg/kg, po pretreated 1 hr before glucose challenge measured up to 120 mins by Oral glucose tolerance test | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4808681 | F | Antidiabetic activity in C57BL/6J mouse assessed as increase in plasma GLP1 level at 10 mg/kg, po measured after 30 mins by ELISA relative control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4808683 | F | Antidiabetic activity in C57BL/6J mouse assessed as increase in plasma GLP1 level at 10 mg/kg, po measured after 30 mins in presence of KR-62436 by ELISA relative to KR-62436 treated control | Mus musculus | 1 | organism-based format | Scientific Literature |
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