# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4831306 | B | Inhibition of CDC7 in human COLO 205 cells assessed as reduction in phosphorylation of MCM2 at 1 uM preincubated for 48 hrs followed by compound washout measured after 24 hrs by Western blot analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
2. | ALA4831307 | B | Reversible inhibition of human CDC7 assessed as off-rate preincubated for 50 mins followed by substrate addition in presence of ATP by rapid dilution assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
3. | ALA4831308 | B | Inhibition of human CDC7/ASK using FITC-labelled MCM2 substrate in presence of 5 uM of ATP | Homo sapiens | 24 | assay format | Scientific Literature | ||
4. | ALA4831309 | B | Inhibition of human CDC7/ASK using FITC-labelled MCM2 substrate in presence of 1 mM of ATP | Homo sapiens | 24 | assay format | Scientific Literature | ||
5. | ALA4831310 | B | Inhibition of human CDC7/ASK using FITC-labelled MCM2 substrate preincubated for 30 mins followed by substrate addition and measured after 5 hrs in presence of 1 mM of ATP | Homo sapiens | 24 | assay format | Scientific Literature | ||
6. | ALA4831311 | B | Inhibition of CDC7 in human COLO205 cells assessed as reduction in MCM2 phosphorylation at S53 residue at 0.1 uM incubated for 48 hrs by Western blot analysis relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
7. | ALA4831312 | F | Induction of cell cycle arrest in human COLO205 cells assessed as accumulation of cells at sub-G1 phase at 1 uM incubated for 48 hrs by propidium iodide staining based flow cytometry analysis | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
8. | ALA4831313 | A | Metabolic stability in human liver microsomes assessed as parent compound remaining after 30 mins | Homo sapiens | 2 | microsome format | Scientific Literature | ||
9. | ALA4831314 | A | Metabolic stability in rat liver microsomes assessed as parent compound remaining after 30 mins | Rattus norvegicus | 1 | microsome format | Scientific Literature | ||
10. | ALA4831315 | A | Metabolic stability in dog liver microsomes assessed as parent compound remaining after 30 mins | Canis lupus familiaris | 1 | microsome format | Scientific Literature | ||
11. | ALA4831316 | A | Metabolic stability in mouse liver microsomes assessed as parent compound remaining after 30 mins | Mus musculus | 2 | microsome format | Scientific Literature | ||
12. | ALA4831317 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
13. | ALA4831318 | A | Protein binding in human plasma assessed as unbound fraction | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
14. | ALA4831319 | B | Inhibition of PIM1 (unknown origin) at 0.1 uM in presence of 1 mM ATP relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
15. | ALA4831320 | B | Inhibition of GSK3alpha (unknown origin) at 0.1 uM in presence of 1 mM ATP relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
16. | ALA4831321 | B | Inhibition of CLK1 (unknown origin) at 0.1 uM in presence of 1 mM ATP relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
17. | ALA4831322 | B | Inhibition of CLK2 (unknown origin) at 0.1 uM in presence of 1 mM ATP relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
18. | ALA4831323 | B | Selectivity index, ratio of IC50 for inhibition of human CDC7 in presence of 1 mM ATP without preincubation to IC50 for inhibition of human CDC7 using FITC-labelled MCM2 substrate preincubated for 30 mins followed by substrate addition and measured after 5 hrs in presence of 1 mM ATP | Homo sapiens | 1 | assay format | Scientific Literature | ||
19. | ALA4831324 | B | Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP without preincubation | Homo sapiens | 1 | single protein format | Scientific Literature | ||
20. | ALA4831325 | B | Inhibition of PIM1 (unknown origin) in presence of 1 mM ATP with preincubation | Homo sapiens | 1 | single protein format | Scientific Literature |