# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4829799 | Binding | Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate at 1 uM by fluorimetric assay relative to control | Homo sapiens | 15 | ALA4828731 | single protein format | Scientific Literature | |
2. | ALA4829800 | Binding | Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetric assay | Homo sapiens | 4 | ALA4828731 | single protein format | Scientific Literature | |
3. | ALA4829801 | Binding | Potency index, ratio of resveratrol IC50 to test compound IC50 for Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetric assay | Homo sapiens | 2 | ALA4828731 | single protein format | Scientific Literature | |
4. | ALA4829802 | Functional | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity up to 50 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 3 | ALA4828731 | cell-based format | Scientific Literature | |
5. | ALA4829805 | Functional | Cytotoxicity against human MCF7 cells assessed as release of LDH up to 250 uM measured after 24 hrs by lactate dehydrogenase assay | Homo sapiens | 3 | ALA4828731 | cell-based format | Scientific Literature | |
6. | ALA4829809 | Functional | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity up to 50 uM incubated for 48 hrs by MTT assay relative to control | Homo sapiens | 3 | ALA4828731 | cell-based format | Scientific Literature | |
7. | ALA4829813 | Functional | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity at 250 uM incubated for 72 hrs by MTT assay relative to control | Homo sapiens | 1 | ALA4828731 | cell-based format | Scientific Literature | |
8. | ALA4829814 | ADME | Cytotoxicity against human HFF-1 clls assessed as reduction in cell viability at 10 to 100 uM measured after 72 hrs by MTT assay | Homo sapiens | 3 | ALA4828731 | cell-based format | Scientific Literature | |
9. | ALA4829816 | Toxicity | Selectivity index, ratio of IC50 for cytotoxicity against human HFF-1 cells to IC50 for cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay | 3 | ALA4828731 | cell-based format | Scientific Literature |