| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4810679 | A | Metabolic stability in human liver microsomes assessed as half life at 2 uM measured up to 30 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 7 | microsome format | Scientific Literature | ||
| 2. | ALA4810680 | P | Kinetic aqueous solubility of the compound in pH 7.4 | 5 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4810681 | A | Metabolic stability in mouse liver microsomes assessed as half life at 2 uM measured up to 30 mins in presence of NADPH by LC-MS/MS analysis | Mus musculus | 4 | microsome format | Scientific Literature | ||
| 4. | ALA4810682 | F | Anti-cryptosporidial activity against Cryptosporidium parvum infected in HCT-8 cells pre-infected for 3 hrs followed by compound treatment and measured after 45 hrs by fluorescence microscopy analysis | Cryptosporidium parvum | 31 | organism-based format | Scientific Literature | ||
| 5. | ALA4810683 | F | Anti-cryptosporidial activity against Cryptosporidium hominis infected in HCT-8 cells pre-infected for 3 hrs followed by compound treatment and measured after 45 hrs by fluorescence microscopy analysis | Cryptosporidium hominis | 3 | organism-based format | Scientific Literature | ||
| 6. | ALA4810685 | F | Anti-cryptosporidial activity against Cryptosporidium parvum infected in HCT-8 cells assessed as rate of parasite elimination at 6 times of EC90 concentration pre-infected for 24 hrs followed by compound treatment | Cryptosporidium parvum | 2 | organism-based format | Scientific Literature | ||
| 7. | ALA4810687 | A | Cytotoxicity against human HCT8 cells assessed as reduction in cell viability after 48 hrs by CellTiter aqueous assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 8. | ALA4810688 | B | Displacement of [3H]-dofetilide from human ERG at 10 uM relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
| 9. | ALA4810689 | B | Inhibition of human ERG expressed in CHO cells at 1 uM by automated patch clamp electrophysiology assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4810690 | B | Inhibition of human ERG expressed in CHO cells at 10 uM by automated patch clamp electrophysiology assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4810691 | B | Inhibition of human ERG expressed in CHO cells at 100 uM by automated patch clamp electrophysiology assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4810694 | A | Efflux ratio of apparent permeability across basolateral to apical side over apical to basolateral side in human MDCKII-MDR1 cells at 10 uM after 2 hrs | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 13. | ALA5260119 | P | Dissociation constant, pKa of compound | 9 | small-molecule physicochemical format | Scientific Literature | |||
| 14. | ALA5260120 | P | Lipophilicity, logP of the compound | 4 | small-molecule physicochemical format | Scientific Literature |
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