# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4821451 | Binding | Inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 15 mins followed by substrate addition measured for every 30 sec by spectrophotometric analysis | Bos taurus | 27 | ALA4819070 | single protein format | Scientific Literature | |
2. | ALA4821452 | Binding | Potency index, ratio of IC50 of allopurinol to IC50 of compound for inhibition of bovine milk xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate preincubated for 15 mins followed by substrate addition measured for every 30 sec by spectrophotometric analysis | Bos taurus | 1 | ALA4819070 | single protein format | Scientific Literature | |
3. | ALA4821453 | Binding | Mixed type inhibition of bovine milk xanthine oxidase assessed as inhibitory constant using xanthine as substrate preincubated for 15 mins followed by substrate addition measured for every 30 sec by spectrophotometric analysis | Bos taurus | 1 | ALA4819070 | single protein format | Scientific Literature | |
4. | ALA4821454 | Binding | Mixed type inhibition of bovine milk xanthine oxidase assessed as inhibitory constant of enzyme-substrate complex using xanthine as substrate preincubated for 15 mins followed by substrate addition measured for every 30 sec by spectrophotometric analysis | Bos taurus | 1 | ALA4819070 | single protein format | Scientific Literature | |
5. | ALA4821456 | Functional | Hypouricemic activity in Sprague-Dawley rat model of Potassium oxonate-induced acute hyperuricemia assessed as decrease in serum uric acid at 10 mg/kg, IG administered after potassium oxonate treatment and measured upto 8 hrs | Rattus norvegicus | 1 | ALA4819070 | organism-based format | Scientific Literature | |
6. | ALA4821457 | Functional | Hypouricemic activity in Sprague-Dawley rat model of Potassium oxonate-induced acute hyperuricemia assessed as decrease in serum uric acid at 30 to 90 mg/kg, IG administered after potassium oxonate treatment and measured at 1 hr | Rattus norvegicus | 1 | ALA4819070 | organism-based format | Scientific Literature | |
7. | ALA4821458 | Functional | Hypouricemic activity in Sprague-Dawley rat model of Potassium oxonate-induced acute hyperuricemia assessed as decrease in serum uric acid AUC (1 to 8 hrs) at 30 to 90 mg/kg, IG administered after potassium oxonate treatment and measured at 1 hr | Rattus norvegicus | 1 | ALA4819070 | organism-based format | Scientific Literature | |
8. | ALA4821459 | Binding | Inhibition of bovine milk xanthine oxidase assessed as increase in Km at 0.01 to 0.06 uM by Lineweaver-Burk plot analysis | Bos taurus | 1 | ALA4819070 | single protein format | Scientific Literature | |
9. | ALA4821460 | Binding | Inhibition of bovine milk xanthine oxidase assessed as decrease in Vmax at 0.01 to 0.06 uM by Lineweaver-Burk plot analysis | Bos taurus | 1 | ALA4819070 | single protein format | Scientific Literature |