| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4829054 | B | Inhibition of recombinant human MMP12 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 2. | ALA4829055 | B | Inhibition of recombinant human MMP10 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 3. | ALA4829056 | B | Inhibition of recombinant human MMP9 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 4. | ALA4829057 | B | Inhibition of recombinant human MMP8 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 5. | ALA4829058 | B | Inhibition of recombinant human MMP7 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 6. | ALA4829059 | B | Inhibition of recombinant human MMP3 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 7. | ALA4829060 | B | Inhibition of recombinant human MMP2 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 8. | ALA4829061 | B | Inhibition of recombinant human MMP1 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 9. | ALA4829062 | B | Inhibition of recombinant human MMP13 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 10. | ALA4829063 | B | Inhibition of recombinant human MMP14 using QXL520-gamma-Abu-Pro-Cha-Abu-Smc-His-Ala-Dab(5-FAM)-Ala-Lys-NH2 as substrate measured every 5 mins for 2 hrs by FRET assay | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 11. | ALA4829064 | A | Stability in rat liver microsomes assessed as parent compound remaining at 1 uM measured after 60 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
| 12. | ALA4829065 | A | AUC (0 to t) in Lewis rat at 1 mg/kg, po measured upto 24 hrs by HPLC-MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4829066 | A | AUC (0 to infinity) in Lewis rat at 1 mg/kg, po measured upto 24 hrs by HPLC-MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 14. | ALA4829067 | A | Apparent terminal elimination half life in Lewis rat at 1 mg/kg, po measured upto 24 hrs by HPLC-MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4829068 | A | Cmax in Lewis rat at 1 mg/kg, po measured upto 24 hrs by HPLC-MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA4829069 | A | Tmax in Lewis rat at 1 mg/kg, po measured upto 24 hrs by HPLC-MS method | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 17. | ALA4829070 | F | Chondro-protective activity in MIA-induced Sprague-Dawley rat osteoarthritis model assessed as reduction in proteoglycan loss on MTP at 1 mg, ia administered once per week for 3 weeks starting from 5 days post MIA treatment and measured after 26 days post MIA injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4829071 | F | Chondro-protective activity in MIA-induced Sprague-Dawley rat osteoarthritis model assessed as reduction in cell loss on lateral tibial plateau at 1 mg, ia administered once per week for 3 weeks starting from 5 days post MIA treatment and measured after 26 days post MIA injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 19. | ALA4829072 | F | Chondro-protective activity in MIA-induced Sprague-Dawley rat osteoarthritis model assessed as reduction of bone resorption at 1 mg, ia administered once per week for 3 weeks starting from 5 days post MIA treatment and measured after 26 days post MIA injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4829081 | F | Chondro-protective activity in MIA-induced Sprague-Dawley rat osteoarthritis model assessed as reduction in proteoglycan loss on LTP at 1 mg, ia administered once per week for 3 weeks starting from 5 days post MIA treatment and measured after 26 days post MIA injection | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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