# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4822135 | B | Binding affinity to Cereblon in human Flp293T cells transfected with BRD4(BD2)-GFP fusion protein and mCherry reporter assessed as inhibition of dBET6-induced BRD4(BD2) degradation after 5 hrs fluorescence based analysis | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
2. | ALA4822137 | B | Protac activity at CRBN/eIF4E in human HEK293T cells assessed as induction of intracellular eIF4E degradation at 0.1 to 10 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
3. | ALA4822138 | B | Protac activity at CRBN/eIF4E in human HEK293T cells assessed as induction of intracellular eIF4E degradation at 1 uM measured after 0.5 to 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
4. | ALA4822139 | B | Protac activity at CRBN/eIF4E in human HEK293T cells assessed as induction of eIF4E ubiquitination at 1 uM in presence of 26S proteasome inhibitor, Bortezomib by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |