| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4842474 | F | Antimalarial activity against asexual blood stage of Plasmodium falciparum assessed as abnormalities in food vacuole observed upto 60 hrs post invasion | Plasmodium falciparum | 3 | organism-based format | Scientific Literature | ||
| 2. | ALA4842475 | A | Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 24 hrs by WST-1 assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 3. | ALA4842476 | B | Inhibition of recombinant Plasmodium falciparum heme detoxification protein expressed in Escherichia coli M15 assessed as reduction in hemozoin formation using heme as substrate measured after 3 hrs relative to control | Plasmodium falciparum | 3 | assay format | Scientific Literature | ||
| 4. | ALA4842477 | B | Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AMC as a substrate measured over 30 mins by fluorometric assay | Plasmodium falciparum | 20 | assay format | Scientific Literature | ||
| 5. | ALA4842478 | B | Inhibition of recombinant Plasmodium falciparum falcipain-2 expressed in Escherichia coli M15 assessed as reduction in free AMC release using Z-FR-AMC as a substrate measured over 30 mins by Cheng-prusoff equation analysis | Plasmodium falciparum | 20 | assay format | Scientific Literature | ||
| 6. | ALA4842479 | F | Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | Plasmodium falciparum | 12 | organism-based format | Scientific Literature | ||
| 7. | ALA4842480 | F | Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum 7G8 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | Plasmodium falciparum | 4 | organism-based format | Scientific Literature | ||
| 8. | ALA4842481 | F | Antimalarial activity against chloroquine, pyrimethamine and mefloquine-resistant Plasmodium falciparum Dd2 assessed as parasite growth inhibition incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | Plasmodium falciparum | 4 | organism-based format | Scientific Literature | ||
| 9. | ALA4842482 | F | Antimalarial activity against asexual blood stage of Plasmodium falciparum assessed as inhibition of mature schizonts development at EC50 observed at 48 hrs post invasion | Plasmodium falciparum | 3 | organism-based format | Scientific Literature | ||
| 10. | ALA4842483 | T | Selectivity index, ratio of EC50 for cytotoxicity against human A549 cells to EC50 for antimalarial activity against Plasmodium falciparum 3D7 | 3 | cell-based format | Scientific Literature | |||
| 11. | ALA4842484 | A | Inhibition of CYP450 (unknown origin) | Homo sapiens | 3 | protein format | Scientific Literature | ||
| 12. | ALA4842485 | F | Selectivity ratio of EC50 for antimalarial activity against Plasmodium falciparum 3D7 to EC50 for Plasmodium falciparum 7G8 | 2 | assay format | Scientific Literature | |||
| 13. | ALA4842486 | A | Drug degradation in human plasma | Homo sapiens | 3 | cell-free format | Scientific Literature | ||
| 14. | ALA4842487 | F | Antimalarial activity against laboratory adapted artemisinin-resistant Plasmodium falciparum RT4974 assessed as inhibition of the survival of ring-stage parasite measured after 66 hrs by ring survival assay | Plasmodium falciparum | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA4842488 | F | Antimalarial activity against blood stage of Plasmodium berghei infected in BALB/c mouse assessed as parasite clearance at 12.5 mg/kg, ip administered once daily for 4 consecutive days measured on day 10 by Giemsa staining based assay (Rvb = 0%) | Plasmodium berghei | 4 | organism-based format | Scientific Literature | ||
| 16. | ALA4842489 | F | Antimalarial activity against blood stage of Plasmodium berghei infected in BALB/c mouse assessed as mouse survival time at 12.5 mg/kg, ip administered once daily for 4 consecutive days (Rvb = 12 to 15 days) | Plasmodium berghei | 4 | organism-based format | Scientific Literature | ||
| 17. | ALA4842490 | F | Potency index, ratio of artemisinin EC50 to test compound EC50 for antimalarial activity against Plasmodium falciparum 3D7 incubated for 48 hrs by SYBR green DNA fluorescent dye-binding assay | Plasmodium falciparum | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4842491 | F | Antimalarial activity against asexual blood stage of Plasmodium falciparum assessed as darkly stained dead parasites at EC50 observed at 60 hrs post invasion | Plasmodium falciparum | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4842492 | F | Antimalarial activity against blood stage of Plasmodium berghei infected in BALB/c mouse assessed as suppression of parasite growth at 12.5 mg/kg, ip administered once daily for 4 consecutive days measured on day 5 by Giemsa staining based assay | Plasmodium berghei | 3 | organism-based format | Scientific Literature | ||
| 20. | ALA4842493 | F | Antimalarial activity against blood stage of Plasmodium berghei infected in BALB/c mouse assessed as suppression of parasite growth at 12.5 mg/kg, ip administered once daily for 4 consecutive days measured on day 6 by Giemsa staining based assay | Plasmodium berghei | 3 | organism-based format | Scientific Literature |
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