# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4835450 | Binding | Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells using PIP2 as substrate preincubated for 15 mins followed by substrate addition and measured after 1 hr by HTRF assay | Homo sapiens | 41 | ALA4834420 | cell-based format | Scientific Literature | |
2. | ALA4835451 | Binding | Selectivity ratio of IC50 for N-terminal His6-tagged recombinant full length human p110alpha/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells to IC50 for N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus infected Sf21 insect cells | Homo sapiens | 41 | ALA4834420 | cell-based format | Scientific Literature | |
3. | ALA4835452 | Binding | Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated for 20 mins followed by anti-IgM antibody stimulation and measured after 30 mins by alphascreen assay | Homo sapiens | 38 | ALA4834420 | cell-based format | Scientific Literature | |
4. | ALA4835453 | Binding | Inhibition of adenosine transporter in human HeLa cells assessed as reduction in [3H]adenosine uptake preincubated for 30 mins followed by [3H]adenosine addition and measured after 60 mins | Homo sapiens | 36 | ALA4834420 | cell-based format | Scientific Literature | |
5. | ALA4835454 | Binding | Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-CD79b antibody-induced CD69 expression preincubated for 60 mins followed by anti-CD79b antibody stimulation and measured after 3 hrs by FACS analysis | Homo sapiens | 12 | ALA4834420 | tissue-based format | Scientific Literature | |
6. | ALA4835455 | ADME | Apparent permeability in pig LLC-PK1 cells | Sus scrofa | 12 | ALA4834420 | cell-based format | Scientific Literature | |
7. | ALA4835456 | Physicochemical | Lipophilicity, log D of the compound by HPLC analysis | 24 | ALA4834420 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4835457 | ADME | Plasma clearance in Wistar Han rat at 0.5 mg/kg, iv or 1 mg/kg, po | Rattus norvegicus | 16 | ALA4834420 | organism-based format | Scientific Literature | |
9. | ALA4835458 | ADME | Intrinsic clearance in Wistar Han rat at 0.5 mg/kg, iv or 1 mg/kg, po | Rattus norvegicus | 16 | ALA4834420 | organism-based format | Scientific Literature | |
10. | ALA4835459 | ADME | Volume of distribution in Wistar Han rat | Rattus norvegicus | 24 | ALA4834420 | assay format | Scientific Literature | |
11. | ALA4835460 | ADME | Unbound volume of distribution in Wistar Han rat | Rattus norvegicus | 24 | ALA4834420 | assay format | Scientific Literature | |
12. | ALA4835461 | ADME | Half-life in Wistar Han rat | Rattus norvegicus | 24 | ALA4834420 | assay format | Scientific Literature | |
13. | ALA4835462 | ADME | Oral bioavailability in Wistar Han rat | Rattus norvegicus | 16 | ALA4834420 | organism-based format | Scientific Literature | |
14. | ALA4835465 | ADME | Plasma clearance in Beagle dog at 0.25 mg/kg, iv or 0.5 mg/kg, po | Canis lupus familiaris | 11 | ALA4834420 | organism-based format | Scientific Literature | |
15. | ALA4835466 | ADME | Intrinsic clearance in Beagle dog at 0.25 mg/kg, iv or 0.5 mg/kg, po | Canis lupus familiaris | 11 | ALA4834420 | organism-based format | Scientific Literature | |
16. | ALA4835467 | ADME | Volume of distribution in Beagle dog | Canis lupus familiaris | 19 | ALA4834420 | assay format | Scientific Literature | |
17. | ALA4835468 | ADME | Unbound volume of distribution in Beagle dog | Canis lupus familiaris | 19 | ALA4834420 | assay format | Scientific Literature | |
18. | ALA4835469 | ADME | Half-life in Beagle dog | Canis lupus familiaris | 19 | ALA4834420 | assay format | Scientific Literature | |
19. | ALA4835470 | ADME | Oral bioavailability in Beagle dog | Canis lupus familiaris | 11 | ALA4834420 | organism-based format | Scientific Literature |