| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4829799 | B | Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate at 1 uM by fluorimetric assay relative to control | Homo sapiens | 15 | single protein format | Scientific Literature | ||
| 2. | ALA4829800 | B | Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetric assay | Homo sapiens | 4 | single protein format | Scientific Literature | ||
| 3. | ALA4829801 | B | Potency index, ratio of resveratrol IC50 to test compound IC50 for Inhibition of human aromatase assessed as reduction in fluorescence intensity using 7-methoxy-4-trifluoromethyl coumarin as a substrate by fluorimetric assay | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 4. | ALA4829802 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity up to 50 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 5. | ALA4829803 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity at 100 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 6. | ALA4829804 | F | Cytotoxicity against human MCF7 cells assessed as fold increase in release of LDH at 50 uM measured after 24 hrs by lactate dehydrogenase assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4829806 | F | Induction of apoptosis in human MCF7 cells assessed as cells in apoptotic stage at 100 uM measured after 24 hrs by Annexin V-APC/PI staining based flow cytometry analysis (Rvb= 7.3%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4829807 | F | Induction of apoptosis in human MCF7 cells assessed as cells in apoptotic stage at 250 uM measured after 24 hrs by Annexin V-APC/PI staining based flow cytometry analysis (Rvb= 7.3%) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4829808 | F | Induction of apoptosis in human MCF7 cells assessed as increase in necrotic cells at 10 to 250 uM measured after 24 hrs by Annexin V-APC/PI staining based flow cytometry analysis relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4829809 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity up to 50 uM incubated for 48 hrs by MTT assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4829810 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell metabolic activity incubated for 72 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 12. | ALA4829811 | F | Cell cycle arrest in human MCF7 cells assessed as reduction in cells in S phase measured after 72 hrs by propidium iodide staining based flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4829812 | F | Cell cycle arrest in human MCF7 cells assessed as increase in cells in G1 phase measured after 72 hrs by propidium iodide staining based flow cytometry analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4829814 | A | Cytotoxicity against human HFF-1 clls assessed as reduction in cell viability at 10 to 100 uM measured after 72 hrs by MTT assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA4829815 | A | Cytotoxicity against human HFF-1 clls assessed as reduction in cell viability at 250 uM measured after 72 hrs by MTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4829816 | T | Selectivity index, ratio of IC50 for cytotoxicity against human HFF-1 cells to IC50 for cytotoxicity against human MCF7 cells measured after 24 hrs by MTT assay | 3 | cell-based format | Scientific Literature | |||
| 17. | ALA4829817 | T | Selectivity index, ratio of IC50 for cytotoxicity against human HFF-1 cells to IC50 for cytotoxicity against human MCF7 cells measured after 48 hrs by MTT assay | 1 | cell-based format | Scientific Literature | |||
| 18. | ALA4829818 | T | Selectivity index, ratio of IC50 for cytotoxicity against human HFF-1 cells to IC50 for cytotoxicity against human MCF7 cells measured after 72 hrs by MTT assay | 1 | cell-based format | Scientific Literature |
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