| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4812956 | Functional | Agonist activity at human GPR119 expressed in CHO cells co-expressing cyclic AMP response element-luciferase reporter gene incubated for 2 hrs by steady-glo luciferase assay | Homo sapiens | 21 | ALA4811273 | cell-based format | Scientific Literature | |
| 2. | ALA4812957 | Binding | Inhibition of human ERG expressed in CHO cells at 10 uM at holding potential of -80 mV by patch clamp method | Homo sapiens | 10 | ALA4811273 | cell-based format | Scientific Literature | |
| 3. | ALA4812959 | ADME | Hepatic clearance in human liver microsomes measured up to 30 mins by LC/MS/MS analysis | Homo sapiens | 3 | ALA4811273 | microsome format | Scientific Literature | |
| 4. | ALA4812960 | ADME | Hepatic clearance in rat liver microsomes measured up to 30 mins by LC/MS/MS analysis | Rattus norvegicus | 3 | ALA4811273 | microsome format | Scientific Literature | |
| 5. | ALA4812961 | Physicochemical | Aqueous solubility of the compound at pH 6.8 by HPLC analysis | 4 | ALA4811273 | small-molecule physicochemical format | Scientific Literature | ||
| 6. | ALA4812962 | Functional | Agonist activity at rat GPR119 expressed in CHO cells co-expressing cyclic AMP response element-luciferase reporter gene incubated for 2 hrs by steady-glo luciferase assay | Rattus norvegicus | 1 | ALA4811273 | cell-based format | Scientific Literature | |
| 7. | ALA4812963 | Functional | Agonist activity at rat GPR119 in golden hamster HIT-T15 cells assessed as induction of glucose-induced insulin secretion after 2 hrs by A1phaLISA | Rattus norvegicus | 1 | ALA4811273 | tissue-based format | Scientific Literature | |
| 8. | ALA4812964 | Functional | Agonist activity at rat GPR119 in GLUTag cells assessed as induction of GLP-1 secretion after 2 hrs by ELISA | Rattus norvegicus | 1 | ALA4811273 | cell-based format | Scientific Literature | |
| 9. | ALA4812965 | ADME | Volume of distribution at steady state in rat at 0.1 mg/kg, iv administered as cassette dose by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4811273 | organism-based format | Scientific Literature | |
| 10. | ALA4812966 | ADME | Clearance in rat at 0.1 mg/kg, iv administered as cassette dose by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4811273 | organism-based format | Scientific Literature | |
| 11. | ALA4812967 | ADME | AUC in rat at 1 mg/kg, po administered as cassette dose by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4811273 | organism-based format | Scientific Literature | |
| 12. | ALA4812968 | ADME | Mean residence time in rat at 1 mg/kg, po administered as cassette dose by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4811273 | organism-based format | Scientific Literature | |
| 13. | ALA4812969 | ADME | Oral bioavailability in rat at 1 mg/kg administered as cassette dose by LC/MS/MS analysis | Rattus norvegicus | 1 | ALA4811273 | organism-based format | Scientific Literature | |
| 14. | ALA4812970 | Functional | Antidiabetic activity in NSTZ1.5 rat assessed as reduction in plasma glucose level at 0.3 to 3 mg/kg, po administered 60 mins prior to glucose challenge and measured up to 60 mins by OGTT | Rattus norvegicus | 1 | ALA4811273 | organism-based format | Scientific Literature | |
| 15. | ALA4812971 | Functional | Antidiabetic activity in orally dosed NSTZ1.5 rat assessed as reduction in insulin level administered 60 mins prior to glucose challenge and measured up to 60 mins by OGTT | Rattus norvegicus | 1 | ALA4811273 | organism-based format | Scientific Literature | |
| 16. | ALA4812972 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 2 | ALA4811273 | microsome format | Scientific Literature |
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